Publications by authors named "Jean-Francois Hamel"

Animal care committees remain ambiguous on the need for anesthetics during experimental procedures on invertebrate taxa due to long-standing questioning of their sentience and pain perception. When used, anesthetizing procedures for invertebrates have commonly been adapted from those developed for vertebrates, under the largely unverified assumption that they afford the same benefits. The present study formally tested the efficacy of four common anesthetics of aquatic invertebrates (ethanol, MgCl, clove oil, MS-222) using behavioural (reaction to physical contact and presence of a predator), physiological (respiration rate), cellular (coelomocytes), and hormonal (cortisol) biomarkers in the holothuroid Cucumaria frondosa (Echinodermata).

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Background: Urinary tract infections are common affections, especially for women. Difficult access to a general practitioner to obtain a prescription has led France to offer dispensing under protocol by community pharmacists. The primary objective of this study is to evaluate the effectiveness of a pharmacist care protocol provided to manage women with urinary tract infection symptoms.

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Background: Postoperative rectovaginal fistula leads to a loss of patients' quality of life and presents significant challenges to the surgeon. The literature focusing specifically on postoperative rectovaginal fistulas is limited. The objective of the present study is to identify factors that can enhance the success of the management of this postoperative rectovaginal fistula.

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A new species of holothuroid, (order Dendrochirotida and family Sclerodactylidae), was discovered off the coast of Labrador (eastern Canada) at a depth of 740-969 m. Two specimens were described based on morphological and genetic parameters. Distinctive characters included pinkish body colour, presence of tube feet on a 'tail', supporting rod-shaped ossicles in the tube feet, and rod-shaped ossicles in the tentacles.

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  • Preoperative imaging, specifically ultrasound (US) and computed tomography (CT), is recommended for patients with suspected acute appendicitis (AA) to improve management outcomes.
  • A retrospective study of 339 patients showed that US was the primary imaging method used, with a small percentage requiring follow-up CT, highlighting a significant association between patient age and management failure.
  • The study concluded that US should be routinely performed as the first-line examination for suspected AA before considering CT, due to its high specificity and reasonable sensitivity, along with the implications for patient management.
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Aim: The aim of this work was to investigate the association between early postoperative anastomotic leakage or pelvic abscess (AL/PA) and symptomatic anastomotic stenosis (SAS) in patients after surgery for left colonic diverticulitis.

Method: This is a retrospective study based on a national cohort of diverticulitis surgery patients carried out by the Association Française de Chirurgie. The assessment was performed using path analyses.

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The intra-ovarian presence of ootids, i.e. female gametes that have completed meiosis, is considered exceptional in the animal kingdom.

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Autotomy refers to self-amputation where the loss of a limb or organ is generally said to be (1) in response to stressful external stimuli; (2) voluntary and nervously mediated; (3) supported by adaptive features that increase efficiency and simultaneously mediate the cost; and (4) morphologically delineated by a predictable breakage plane. It is estimated that this phenomenon has evolved independently nine different times across the animal kingdom, appearing in many different taxa, including vertebrate and invertebrate as well as aquatic and terrestrial animals. Marine invertebrates use this behaviour in a diversity of manners that have yet to be globally reviewed and critically examined.

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  • In patients with acute myeloid leukemia (AML), a higher presence of Vγ9Vδ2 T cells at diagnosis is associated with better overall and relapse-free survival rates.
  • This study analyzed immunophenotypic data from 198 newly diagnosed AML patients to determine how Vγ9Vδ2 T-cell frequency impacts prognosis while adjusting for various confounding factors.
  • The findings support the importance of Vγ9Vδ2 T cells in AML prognosis and suggest potential treatment strategies that could boost these T-cell responses in patients.
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  • * Out of 227 women surveyed, 19.8% reported ongoing AI, while 35.2% experienced AI episodes at some point, significantly impacting their quality of life across all assessed areas.
  • * The findings indicated that post-obstetrical AI lasting longer than 6 months is common, associated with increased parity and BMI, while instrumental births appeared to provide some protection against chronic AI.
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  • The study examined maternal and neonatal outcomes from deliveries in France in 2019, focusing on hospital characteristics, travel distance, and travel time.
  • Out of 733,052 pregnancies, there were 10,829 cases of severe maternal morbidity (1.48%) and 77,237 cases of neonatal adverse outcomes (10.4%), with factors like obstetric comorbidity and cesarean delivery affecting these outcomes.
  • The findings indicate the effectiveness of regionalized perinatal care, recommending improved organization of high-volume maternity units and consolidation of low-volume ones to enhance care quality.*
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Competitive interactions come in a variety of forms and may be modulated by the size and number of individuals involved, and/or the resources available. Here, intra- and interspecific competitive behaviours for food (i.e.

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Background: Lung point-of-care ultrasonography (L-POCUS) is highly effective in detecting pulmonary peripheral patterns and may allow early identification of patients who are likely to develop an acute respiratory distress syndrome (ARDS). We hypothesized that L-POCUS performed within the first 48 hours of non-critical patients with suspected COVID-19 would identify those with a high-risk of worsening.

Methods: POCUSCO was a prospective, multicenter study.

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  • * It analyzed data from 60 children over four treatment phases, noting the percentage of time their glucose levels stayed in the target range while considering missed boluses.
  • * Results indicate that HCL therapy consistently improved glycemic control compared to SAP, even when meal insulin was missed, suggesting HCL may be the better choice for managing diabetes in children.
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Our aim was to identify factors associated with shoulder dystocia following an attempted operative vaginal delivery (aOVD) in a prospective cohort study and to evaluate whether these factors can be used to accurately predict shoulder dystocia by building a score of shoulder dystocia risk. This was a planned secondary analysis of a prospective cohort study of deliveries with aOVD at term from 2008-2013. Cases were defined as women with shoulder dystocia following an aOVD defined as a delivery that requires additional obstetric maneuvers following failure of gentle downward traction on the fetal head to effect delivery of the shoulders.

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Background: Identifying the 30% of adhesive small bowel obstructions (aSBO) for which conservative management will require surgery is essential. The association between the previously described radiological score and failure of the conservative management of aSBO remains to be confirmed in a large prospective multicentric cohort. Our aim was to assess the risk factors of failure of the conservative management of aSBO considering the radiological score.

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  • Enterococcus faecalis infective endocarditis (EFIE) has a higher relapse rate compared to other types of infective endocarditis, and this study explores the influence of different antibiotic treatments on these relapses.
  • The research involved 279 patients from 14 hospitals in France, analyzing the occurrence of relapses within one year following diagnosis, using specific statistical models to account for competing risks like death.
  • Results showed that relapses are common (9.3% in one year) and can even be asymptomatic, with surgery during treatment noted as a protective factor; the relapse rates varied significantly based on the type of antibiotic regimen used.
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  • * At two weeks post-demise, 44.2% of women showed significant PTSD symptoms, decreasing to 34.1% at one month and 9.1% at three months.
  • * Key risk factors for developing PTSD included experiencing peritraumatic dissociation, seeing or holding the fetus, and organizing a funeral service. Care providers should be alert to these risk factors for better patient support.
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In claudication, the correlation between walking-induced biomarkers and indices of clinical severity (e.g., walking distance or ankle brachial index (ABI)), is fair.

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