Publications by authors named "Jean-Francois Coste"
Article Synopsis
- Diarrhea is a common issue post-kidney transplant, mainly due to immunosuppressive therapies, prompting the need for better diagnostic methods when stool tests are negative.
- A study found that molecular testing methods identified enteric pathogens in 72% of stool samples, significantly higher than the 23% found using traditional methods, and also revealed multiple infections in some patients.
- The primary pathogens identified were E. coli, Campylobacter, and Norovirus, with Norovirus associated with more significant weight loss and linked to specific medication risks, highlighting the advantages of molecular diagnostics for managing diarrhea in transplant recipients.
Although numerous reports have described inflammatory bowel diseases (IBDs) complicated with cytomegalovirus (CMV) infection, the virus participation as an exacerbating factor remains unclear. The aim of this study was thus to clarify the clinical significance of CMV infection complicating exacerbation and to correlate CMV detection with various characteristics in IBD patients. Sixty-seven colonic biopsies obtained from 53 patients admitted for IBD exacerbation were retrospectively analyzed by real-time PCR assay.
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