Publications by authors named "Jean-Francois Carmel"
Article Synopsis
- Alpha-synucleinopathies, including Parkinson's disease and related conditions, show significant sex differences in symptoms, particularly neuropsychiatric symptoms (NPS).
- A systematic review of 240 studies with over 796,000 participants revealed that females generally experience higher rates of anxiety, depression, fatigue, and psychotic symptoms, while males have more prevalence of apathy and impulse control issues.
- These findings highlight the need to consider sex differences when developing clinical assessments and treatments for these disorders.
Background: Psychosis in Alzheimer disease (AD) is a major burden for patients and their family. Identifying the characteristics of delusions and hallucinations in the AD population is key to understanding the interconnection between the psychiatric and cognitive symptoms in neurocognitive disorders. The aim of this study is to compare the cognitive profiles of AD patients with and without psychosis.
View Article and Find Full Text PDFOxidative stress in adipose tissue constitutes a pathological process involved in obesity-linked metabolic disorders. Apolipoprotein E (apoE), which exhibits antioxidant properties in plasma and brain, is highly produced by adipose tissue and adipocytes. In this study, we investigated the role of apoE in the human adipocyte response to oxidative stress.
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- - The study investigates the effects of high apolipoprotein E (apoE) expression on the differentiation and proliferation of human adipocytes (SW872 cells), finding that increased apoE reduces lipid accumulation in these cells.
- - ApoE-transfected cells showed lower levels of triglycerides and cholesterol and exhibited a downregulation of important genes related to fat storage and metabolism, indicating impaired lipid accumulation.
- - Additionally, apoE-high cells demonstrated greater resistance to serum deprivation and increased cell division compared to control cells, suggesting a significant role of apoE in metabolic health at the fat cell level.
Downregulation of ENaC activity and expression by TNF-alpha in alveolar epithelial cells.
Am J Physiol Lung Cell Mol Physiol
February 2004
Sodium absorption by an amiloride-sensitive channel is the main driving force of lung liquid clearance at birth and lung edema clearance in adulthood. In this study, we tested whether tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine involved in several lung pathologies, could modulate sodium absorption in cultured alveolar epithelial cells. We found that TNF-alpha decreased the expression of the alpha-, beta-, and gamma-subunits of epithelial sodium channel (ENaC) mRNA to 36, 43, and 16% of the controls after 24-h treatment and reduced to 50% the amount of alpha-ENaC protein in these cells.
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