Publications by authors named "Jean-Fabrice Nsota Mbango"
Am J Hum Genet
December 2019
Article Synopsis
- Structural defects in sperm flagella lead to asthenozoospermia, a common issue in infertile men, particularly seen as "short tails" (MMAF).
- Research on 167 individuals with MMAF revealed that over 30% had harmful mutations, notably in the TTC29 gene, which is crucial for sperm flagellar function.
- Further studies in model organisms confirmed that TTC29 is vital for maintaining proper sperm flagellum structure and movement, linking its mutations to male infertility.
Basic Clin Androl
March 2019
Article Synopsis
- - Male infertility caused by Multiple Morphological Abnormalities of sperm Flagella (MMAF) leads to severe motility issues in sperm, characterized by various abnormalities in flagella structure.
- - Recent research identified 7 new genes linked to MMAF, accounting for about 45% of cases studied, using advanced sequencing technologies and validation methods in animal models.
- - Understanding these genes not only enhances the diagnosis of male infertility but also may inform treatment options like intracytoplasmic sperm injection (ICSI) and shed light on the biology of sperm flagellum function.
