NF-1Score: a prediction score for internal neurofibromas in neurofibromatosis-1.

NF-1 is associated with a 15-year decrease in life expectancy. Internal neurofibromas are associated with increased morbidity and mortality through malignant transformation and compression of neighboring organs. Our purpose was to develop and to validate a clinical score for predicting internal neurofibromas in adults.

Retrospective French nationwide survey of childhood aggressive vascular anomalies of bone, 1988-2009.

Objective: To document the epidemiological, clinical, histological and radiological characteristics of aggressive vascular abnormalities of bone in children.

Study Design: Correspondents of the French Society of Childhood Malignancies were asked to notify all cases of aggressive vascular abnormalities of bone diagnosed between January 1988 and September 2009.

Results: 21 cases were identified; 62% of the patients were boys.

[History of orthopaedic surgery and "the gang of four"].

Four practitioners, Victor Menard, François Calot, Jacques Calvé, Etienne Sorel were the prominent surgeons in the Hospital of Berck sur Mer. They tried to set a real resistance against the terrible disease : the articular tuberculosis. Each of them proposed a means either of diagnosis or classification or surgical treatment.