Automatic detection of microaneurysms in color fundus images.

This paper addresses the automatic detection of microaneurysms in color fundus images, which plays a key role in computer assisted diagnosis of diabetic retinopathy, a serious and frequent eye disease. The algorithm can be divided into four steps. The first step consists in image enhancement, shade correction and image normalization of the green channel.

Anti-angiogenic properties of myo-inositol trispyrophosphate in ovo and growth reduction of implanted glioma.

We investigate here the anti-angiogenic properties of the synthetic compound myo-inositol trispyrophosphate (ITPP). By increasing oxy-haemoglobin dissociation, ITPP has the potential to counteract the effects of hypoxia, a critical regulator of angiogenesis and cancer progression. ITPP inhibited angiogenesis of the chorioallantoic membrane (CAM), as analyzed with an original program dedicated to automated quantification of angiogenesis in this model.

Redistribution of the neurosensory retina in inferior limited macular translocation: an evaluation using image registration.

Background: The present work aims to demonstrate the role of redistribution of the neurosensory retina (RNR)-that is, retinal tissue stretching and compression-in inferior limited macular translocation (LMT), to perform displacement mapping all over the area centralis, and to try and improve displacement evaluation precision.

Methods: Using piecewise linear image registration (through Matlab) on indocyanine green angiographic frames, we have evaluated the deformation (on both the retinal and choroido-scleral layer) of a pre-operative grid superimposed on the area centralis, plotted displacement vectors all over the area centralis, and calculated a scale ratio between pre- and post-operative frames. The scale ratio tests whether or not the same physical distance is represented by the same distance on these frames.

A contribution of image processing to the diagnosis of diabetic retinopathy--detection of exudates in color fundus images of the human retina.

In the framework of computer assisted diagnosis of diabetic retinopathy, a new algorithm for detection of exudates is presented and discussed. The presence of exudates within the macular region is a main hallmark of diabetic macular edema and allows its detection with a high sensitivity. Hence, detection of exudates is an important diagnostic task, in which computer assistance may play a major role.

Prevention of hypoglycemia using risk assessment with a continuous glucose monitoring system.

Due to the lag between sugar intake and the beginning of recovery from hypoglycemia, it is necessary to intervene in an anticipatory way if one wants to prevent, not only detect, hypoglycemia. This article presents the principle of a hypoglycemia prevention system based on risk assessment. The risk situation can be defined as the moment when the system estimates that the glucose concentration is expected to reach a hypoglycemia threshold in less than a given time (e.

A new amperometric glucose microsensor: in vitro and short-term in vivo evaluation.

For biosensor fabrication, it is important to optimize materials and methods in order to create predictable function in vitro and in vivo. For this reason, we designed a new glucose sensor ('revised protocol') that utilized an outer permselective membrane made of amphiphobic polyurethane which allows glucose passage through hydrophilic segments. An inner polyethersulfone membrane, stabilized with a trimethoxysilane, provided specificity.