Pancreatic Cancer Progression in a Patient With Lynch Syndrome Receiving Immunotherapy: A Cautionary Tale.

Pancreatic ductal adenocarcinomas (PDACs) with DNA mismatch repair deficiency (MMRd) respond preferentially to immune checkpoint inhibitors (ICIs). However, a subset of MMRd PDACs does not respond to these agents. This report describes a patient with PDAC who experienced rapid disease progression suggestive of hyperprogressive disease.

New methodology for specific inhalation challenges with occupational agents.

Background: Inhalation challenges are used for diagnosing occupational asthma (OA). The initial methodology consisted of a "realistic" exposure without monitoring nor controlling exposure. Our aim was to design an equipment, called the GenaSIC, that allows the generation of various agents regardless of the formulation and to assess the feasibility of its use in patients investigated for OA.

Conjectured strong complementary information tradeoff.

We conjecture a new entropic uncertainty principle governing the entropy of complementary observations made on a system given side information in the form of quantum states, generalizing the entropic uncertainty relation of Maassen and Uffink [Phys. Rev. Lett.