F-FDG PET/CT versus Diagnostic Contrast-Enhanced CT for Follow-Up of Stage IV Melanoma Patients Treated by Immune Checkpoint Inhibitors: Frequency and Management of Discordances over a 3-Year Period in a University Hospital.

Aim: To perform a comprehensive analysis of discordances between contrast-enhanced CT (ceCT) and F-FDG PET/CT in the evaluation of the extra-cerebral treatment monitoring in patients with stage IV melanoma.

Materials And Methods: We conducted a retrospective monocentric observational study over a 3-year period in patients referred for F-FDG PET/CT and ceCT in the framework of therapy monitoring of immune checkpoint (ICIs) as of January 2017. Imaging reports were analyzed by two physicians in consensus.