Publications by authors named "Jean-Baptiste Causin"

Article Synopsis
  • The study focuses on treatment-resistant depression (TRD) characterized by anergic-anhedonic symptoms, proposing a two-step therapy called the Dopaminergic Antidepressant Therapy Algorithm (DATA) combining monoamine oxidase inhibitors and dopamine D2 receptor agonists.
  • Out of 52 patients treated with DATA, 48 were analyzed, showing significant remission rates: 52% after the first step and 77% after the second, highlighting the effectiveness of this approach over a median follow-up of 4 months.
  • The findings suggest that TRD patients respond well to pro-dopaminergic treatments, but some variability in patient responses indicates a need for better understanding of dopamine-sensitive depression forms.
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Background: Racing thoughts have been found in several states of bipolar disorder (BD), but also in healthy populations with subclinical mood alterations. The evaluation of racing thoughts relies on subjective reports, and objective measures are sparse. The current study aims at finding an objective neuropsychological equivalent of racing thoughts in a mixed group of BD patients and healthy controls by using a bistable perception paradigm.

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Bistable stimuli can give rise to two different interpretations between which our perception will alternate. Recent results showed a strong coupling between eye movements and reports of perceptual alternations with motion stimuli, which provides useful tools to objectively assess perceptual alternations. However, motion might entrain eye movements, and here we check with a static picture, the Necker cube, whether eye movements and perceptual reports (manual responses) reveal similar or different alternation rates, and similar or different sensitivity to attention manipulations.

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Background: Racing and crowded thoughts are frequently reported respectively in manic and mixed episodes of bipolar disorder (BD). However, questionnaires assessing this symptom are lacking. Here we aimed to investigate racing thoughts across different mood episodes of BD through a self-report questionnaire that we developed, the 34-item Racing and Crowded Thoughts Questionnaire (RCTQ).

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