Publications by authors named "Jean-Baptiste Baudey"
Article Synopsis
- Lung transplantation often faces challenges due to acute or chronic rejection, linked to the presence of HLA donor-specific antibodies and other autoantibodies.
- Non-classical HLA molecules, such as HLA-G, play a role in immune acceptance of lung grafts; certain isoforms are associated with poorer outcomes in transplants.
- The study aimed to investigate HLA-G antibody prevalence in lung transplant recipients, finding specific antibody reactivity rare, with non-specific responses indicating possible issues with autoantigens in the testing cells.
In an ineffective transfusion context, solid-phase immunoassays using the Luminex platform for the detection and characterization of HLA antibodies are currently used to select HLA-compatible platelet products. A new HLA antibody identification method, the HISTO SPOT® HLA AB test (BAG Health care GmbH, Lich, Germany), based on the detection of antibodies directed against a recombinant single antigen (SA) by colored spots detected by HISTO MATCH HLA AB module software, runs fully automated on the MR.SPOT®.
View Article and Find Full Text PDFBackground: Many studies have reported the relevance of donor-derived cfDNA (dd-cfDNA) after lung transplantation (LTx) to diagnose and monitor acute rejection (AR) or chronic rejection or infection (INF). However, the analysis of cfDNA fragment size has not been studied. The aim of this study was to determine the clinical relevance of dd-cfDNA and cfDNA size profiles in events (AR and INF) during the first month after LTx.
View Article and Find Full Text PDFComplement-dependent lymphocytotoxicity cross match (CDC-XM) is the ultimate test of donor/recipient compatibility prior to organ transplantation. This test is based on cell viability, evaluated under fluorescence microscopy by an operator after proper staining. The determination of the positivity threshold may vary depending on the operator.
View Article and Find Full Text PDFBackground: Transfusion of defective platelets could contribute to the inefficiency of platelet transfusion in preventing or stopping bleeding.
Study Design And Methods: This single-center prospective study aimed to determine the prevalence of functional platelet abnormalities in a population of blood donors with a clinical history of bleeding diathesis or with history of hematoma (>4 cm) during blood donation. Donors with positive bleeding screening questionnaire were referred to the reference center for rare platelet diseases at La Timone University Hospital (Marseille) to confirm the bleeding tendency using a more extensive bleeding questionnaire (MCMDMscore) and to assess hemostasis, including a comprehensive platelet analysis.