Publications by authors named "Jean Shanaa"
Background: Hip resurfacing arthroplasty (HRA) offers numerous benefits over total hip replacements such as increased preservation of natural bone, improved range of motion, and lower dislocation risks. However, patient selection is crucial, with factors such as bone quality, activity level, and body mass index (BMI) playing significant roles. Obesity in particular poses challenges, potentially increasing mechanical load on the joint, complicating surgical techniques, and affecting both immediate and long-term outcomes.
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- There is a critical need for better COVID-19 therapies, with the main protease M being an important target for antiviral treatments.
- Researchers identified a terminal alkyne as an effective covalent inhibitor of M, leading to irreversible modification that disrupts the virus's replication.
- The study produced clickable probes to assess how these inhibitors interact with the target, showing that alkyne-containing compounds effectively reduced SARS-CoV-2 infection in lab models.