Oligandrin from (Euphorbiaceae) exhibits anti-breast cancer activity through immune-boosting mechanisms: and study.

Aim: Recent developments in cancer research indicate that cancer is a manifestation of immune system dysfunction. Many natural anticancer agents developed recently possess immune-modulatory properties. In our ongoing pursuit of anticancer alternatives, we evaluated the immune-modulatory potential of oligandrin, an ent-pimarane type diterpenoid from .

Constituents of the Stem Bark of Linn. f. with Antileishmanial and Antibacterial Activities.

The chemical investigation of the -hexane fraction from the methanol extract of the stem bark of Linn f., which displayed good in vitro activity against NR-48822 promastigotes (IC 43.11 µg/mL), led to the isolation of three previously unreported polyprenylated benzophenones, guttiferone U (), V ()/W (), and a new tocotrienol derivative named globuliferanol (), along with 11 known compounds (-).

Constituents of the Stem Bark of (Thonn.) J. J. De Wilde (Meliaceae) and Their Antibacterial and Antiplasmodial Activities.

The chemical investigation of the EtOH extract from the stem bark of (Thonn.) J. J.

Crotofoligandrin, a new endoperoxide crotofolane-type diterpenoid from the twigs of Pierre ex. Hutch (Euphorbiaceae).

Crotofoligandrin (), a new endoperoxide crotofolane-type diterpenoid was isolated from the dichloromethane/methanol (1:1) extract of the twigs of Pierre Ex Hutch along with thirteen known secondary metabolites including 1-nonacosanol (), lupenone (), friedelin (), -sitosterol (), taraxerol (), (-)-hardwickiic acid (), apigenin (), acetyl aleuritolic acid (), betulinic acid (), fokihodgin C 3-acetate (), D-mannitol (), scopoletin () and quercetin (). The structures of the isolated compounds were determined based on their spectroscopic data. The crude extract and the isolated compounds were assessed for their antioxidant, lipoxygenase, butyrylcholinesterase (BChE), urease and glucosidase inhibitory potentials.

Antibacterial constituents of spreng and its emodin derivatives.

The CHCl-MeOH (1:1) extract of roots of (Polygonaceae) displayed significant antibacterial activity against five bacterial strains with MICs (62.5-31.2 μg.

Bioactive Arylnaphthalide Lignans from .

Eleven previously undescribed arylnaphthalide lignans (-) together with seven known compounds were isolated from the whole plant of . The structures of - were elucidated by spectroscopic analysis and mass spectrometry. Compounds (IC = 4.

Antioxidant and cytotoxicity activities of δ-tocotrienol from the seeds of .

Chemical investigation of P. Beauv fruits led to the isolation of a new -tocotrienol, 3-hydroxy-δ-tocotrienol () together with eight known compounds (-). Compound ( was allylated () and prenylated ( and ) to give three new semi-synthesized derivatives which were fully characterized as: 6--allyl-3-hydroxy-δ-tocotrienol (), 6--prenyl-3-hydroxy-δ-tocotrienol () and 6-,5-C-diprenyl-3-hydroxy-δ-tocotrienol ().

Phytochemical, antibacterial, antioxidant and cytoxicity investigation of .

The phytochemical investigation of led to the isolation of 18 known compounds of which were four flavones, three anthraquinones, one phenyl propanoic derivative, five triterpenoids, four steroids and a mixture of glucose. Luteolin () and soranjidiol () were allylated and/or prenylated to give four new semisynthesized derivatives which were fully characterized as 7,3',4'--triallylluteolin (), luteolin-7,3',4'--triprenyls (), luteolin-5,7,3',4'--tetraprenyls () and 6--allylsoranjidiol (). Their structures were established using spectroscopic analysis including 1D, 2D NMR and MS data.

Antibacterial secotirucallane triterpenes from the stem bark of Pseudocedrela kotschyi.

The antibacterial-guided investigation of the stem bark extract of Pseudocedrela kotschyi led to the isolation of a new secotirucallane triterpene derivative: 4-hydroxy-3,4-secotirucalla-7,24-dien-3,21-dioic acid (1), together with the known one: 3,4-secotirucalla-4(28),7,24-trien-3,21-dioic acid (2) and 3-methyl ester 3,4-secotirucalla-4(28),7,24-trien-3,21-dioic (3). The structures of the isolated compounds were elucidated on the basis of extensive 1D- and 2D-NMR spectroscopy. Extracts, fractions and compounds (1-3) were tested in vitro for antibacterial activity against two Gram positive bacteria (Bacillus subtilis and Staphylococcus aureus ATCC 25923), and two Gram negative bacteria (Escherichia coli S2(1) and Pseudomonas aeruginosa).

Ceanothane-type triterpenoids from Cyphostemma adenocaule.

Phytochemical investigation of the methanol extract of Cyphostemma adenocaule liana (bark and wood) led to the isolation of two new ceanothane-type triterpenoids, cyphostemmic acid A 1 and cyphostemmic acid B 2, together with the known triterpenoids 3-7, β-sitosterol and its glucoside. The structures of the isolated compounds were established by 1D- and 2D-NMR spectroscopy. Ozonolysis of cyphostemmic acid A 1, epigouanic acid A 3 and betulin 6 yielded semisynthetic derivatives, cyphostemmic acid C 8, cyphostemmic acid D 9, and 3β,28-dihydroxy-30-norlupan-20-one 10 respectively.

Antimicrobial triterpenes from the stem bark of Crossopteryx febrifuga.

Phytochemical investigation of the stem bark extract of Crossopteryx febrifuga resulted in the isolation of epimeric mixtures of 3β-urs-12,20(30)-diene-27,28-dioic acid and 18-epi-3β-urs-12,20(30)-diene-27,28-dioic acid (1), as well as: 3β-D-glucopyranosylurs-12,20(30)-diene-27,28-dioic acid and 18-epi-3β-D-glucopyranosylurs-12,20(30)-diene-27,28-dioic acid (2), together with some known compounds such as the monoglyceride of palmitic acid, as well as β-sitosterol and its glucoside. The structures of the isolated compounds were determined by application of spectroscopic methods. The MeOH extract and compounds 1 and 2 were examined for antimicrobial activity in in vitro assays against bacteria (Enterobacter aerogenes ATCC13048, Escherichia coli ATCC8739, Klebsiella pneumoniae ATCC11296, Staphylococcus aureus) and fungi (Candida parapsilosis, Candida albicans ATCC 9002 and Cryptococcus neoformans IP 90526).

Endiandric Acid Derivatives and Other Constituents of Plants from the Genera Beilschmiedia and Endiandra (Lauraceae).

Plants of the Lauraceae family are widely used in traditional medicine and are sources of various classes of secondary metabolites. Two genera of this family, Beilschmiedia and Endiandra, have been the subject of numerous investigations over the past decades because of their application in traditional medicine. They are the only source of bioactive endiandric acid derivatives.

Procerenone: a Fatty Acid Triterpenoid from the Fruit Pericarp of Omphalocarpum procerum (Sapotaceae).

Phytochemical investigation of a dichloromethane-methanol (1:1) extract of the fruit pericarp of Omphalocarpum procerum which exhibited antiplasmodial activity during preliminary screening led to the isolation of the new fatty ester triterpenoid 3β-hexadecanoyloxy-28-hydroxyolean-12-en-11-one (1), together with five known compounds 2-6. The structure of the new compound as well as those of the known compounds was established by means of spectroscopic methods and by comparison with previously reported data. Compounds 1- 4 were evaluated in-vitro for their cytotoxicity against L6 cell lines and antiprotozoal activities against Plasmodium falciparum, Leishmania donovani, Trypanosoma brucei rhodesiense and Trypanosoma cruzi (species responsible for human malaria, visceral leishmaniasis, African trypanosomiasis and Chagas disease, respectively).

Anticancer and antimicrobial activities of some antioxidant-rich cameroonian medicinal plants.

Traditional remedies have a long-standing history in Cameroon and continue to provide useful and applicable tools for treating ailments. Here, the anticancer, antimicrobial and antioxidant activities of ten antioxidant-rich Cameroonian medicinal plants and of some of their isolated compounds are evaluated.The plant extracts were prepared by maceration in organic solvents.

Bioactive constituents of the stem bark of Beilschmiedia zenkeri.

Phytochemical investigation of the stem bark of Beilschmiedia zenkeri led to the isolation of four new methoxylated flavonoid derivatives, (2S,4R)-5,6,7-trimethoxyflavan-4-ol (1), (2S,4R)-4,5,6,7-tetramethoxyflavan (2), beilschmieflavonoid A (3), and beilschmieflavonoid B (4), together with seven known compounds. The structures of 1-4 were established by spectroscopic methods, and their relative configurations confirmed by X-ray crystallographic and CD analysis. The isolated compounds were evaluated in vitro for their antibacterial activity against three strains of bacteria, Pseudomonas agarici, Bacillus subtilis, and Streptococcus minor, and for their antiplasmodial activity against Plasmodium falciparum, chloroquine-resistant strain W2.

Antibacterial endiandric acid derivatives from Beilschmiedia anacardioides.

Three endiandric acid derivatives, beilschmiedic acids A, B and C were isolated from the stem bark of Beilschmiedia anacardioides together with the known beta-sitosterol. Their structures were established by means of modern spectroscopic techniques. The relative configuration of compound 1 was determined by single crystal X-ray analysis.