Endogenous nitric oxide modulates small intestinal nutrient transit and activity in healthy adult humans.

Objective: Nitric oxide (NO) mechanisms have been shown to modulate fasting small intestinal motility in humans, but a role in the regulation of human postprandial small intestinal motility has not been assessed. The aim of this study was to evaluate the effect of the NO synthase inhibitor NG-monomethyl-L-arginine (L-NMMA) on the regulation of small intestinal nutrient transit and postprandial small intestinal motility in healthy humans.

Material And Methods: Seven healthy male volunteers (18-27 years) underwent antroduodenal manometry recordings for 4 h on 2 occasions after intraduodenal instillation of a 500 KJ [120 Kcal] test meal.

Simultaneous monitoring of noninvasive hemodynamic profile and capnography for tissue perfusion evaluation.

To study the simultaneous variations of end-tidal CO pressure (PetCO) and aortic blood flow (ABF) during modifications of tissue perfusion, continuous noninvasive hemodynamic monitoring and continuous recording of PetCO were performed on 30 patients under general anesthesia and artificial mechanical ventilation. The 30 patients underwent orthopedic surgery on one of the lower limbs using a hemostatic tourniquet. Deflation of the pneumatic tourniquet resulted in a rise of ABF up to 39% (P<0.