Publications by authors named "Jean Pierre Schatzmman Peron"
Human Fallopian Tube - Derived Mesenchymal Stem Cells Inhibit Experimental Autoimmune Encephalomyelitis by Suppressing Th1/Th17 Activation and Migration to Central Nervous System.
Carla Longo de Freitas Carolina Manganeli Polonio Wesley Nogueira Brandão Cristiano Rossato Nágela Ghabdan Zanluqui Jean Pierre Schatzmman Peron
Stem Cell Rev Rep
February 2022
Article Synopsis
- Mesenchymal stem cells (MSCs) are undifferentiated cells found in adult tissues that show promise for treating various diseases due to their ability to renew and differentiate into different cell types while modulating immune responses.
- This study focused on human tubal mesenchymal stem cells (htMSCs) and their effects in an experimental autoimmune encephalomyelitis (EAE) model, revealing their ability to suppress the activation of dendritic cells and promote anti-inflammatory cytokine release.
- Results indicated that htMSCs lead to milder disease symptoms, with reduced immune cell infiltration and increased levels of protective factors, suggesting their potential as a therapy for inflammatory and neurodegenerative conditions.