Very high alpha-tocopherol diet diminishes oxidative stress and hypercoagulation in hypertensive rats but not in normotensive rats.

Background: Oxidative stress is closely related to cardiovascular diseases, such as atherosclerosis. Increasing dietary antioxidants, such as alpha-tocopherol, may prevent these diseases. However, in some pathologies, such as hypertension, oxidative stress is enhanced, thus alpha-tocopherol requirements may be raised.