Publications by authors named "Jean P Achkar"
Studies report favorable efficacy and safety profiles of ustekinumab (UST) and vedolizumab (VDZ) in Crohn's disease (CD), but effectiveness and safety data in elderly patients with CD is lacking. We retrospectively analyzed 78 elderly patients (39 each UST and VDZ) and found that patients on UST and VDZ experienced similar rates of clinical response, remission and mucosal healing despite high proportion of prior biologic exposure. Both UST and VDZ appear to be effective and safe in this at-risk CD population.
View Article and Find Full Text PDFBackground: Postoperative recurrence [POR] of Crohn's disease following ileocolonic resection is common. The impact of immediate postoperative intra-abdominal septic complications [IASC] on endoscopic and surgical recurrence has not been elucidated.
Aims: To evaluate if IASC is associated with an increased risk for endoscopic and surgical POR.
Unlabelled: There are conflicting data assessing the impact of isolated post-operative anastomotic inflammation on future disease progression. The aim of this study was to determine the relative risk of severe disease progression in post-operative Crohn's disease (CD) patients with isolated anastomotic disease.
Methods: Retrospective cohort study of adult CD patients undergoing ileocolonic resection between 2009 and 2020.
Background & Aims: Postoperative Crohn's disease (CD) surveillance relies on endoscopic monitoring. The role of cross-sectional imaging is less clear. We evaluated the concordance of cross-sectional enterography with endoscopic recurrence and the predictive ability of radiography for future CD postoperative recurrence.
View Article and Find Full Text PDFArticle Synopsis
- The study evaluates the safety and effectiveness of ustekinumab (UST) in elderly patients (65 years and older) with Crohn's disease (CD), given the lack of existing data for this age group.
- A total of 117 patients were analyzed, finding that while both elderly and nonelderly patients had a similar clinical response to UST, elderly patients had lower rates of complete remission.
- The study concludes that UST is safe for elderly CD patients, although the findings are based on a small sample size and retrospective design, suggesting the need for further research in this area.
Chronic inflammatory diseases, depending upon the duration and severity, are frequently associated with an increased risk of developing cancer. A classic paradigm is the enhanced risk of colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD). Carcinogenesis is a multifactorial process that involves accumulation of genetic defects, protein modification, and cell-matrix interaction.
View Article and Find Full Text PDFPurpose: Plasma levels of lysophospholipids were evaluated as potential biomarkers for colorectal cancer (CRC), where a highly reliable and minimally invasive blood test is lacking.
Patients And Methods: Patients with CRC (n = 133) and control subjects (n = 125) were recruited through the Cleveland Clinic. Preoperative plasma samples were analyzed for lysophospholipid levels using liquid chromatography mass spectrometry in a blinded fashion.