Publications by authors named "Jean Mossman"
Background: Patient and public involvement in health economic evaluation is still relatively rare, compared to other areas of health and social care research. Developing stronger patient and public involvement in health economic evaluation will be important in the future because such evaluations can impact on the treatments and interventions that patients can access in routine care.
Main Text: The Consolidated Health Economic Evaluation Reporting Standards (CHEERS) is a reporting guideline for authors publishing health economic evaluations.
Article Synopsis
- - The research aimed to understand the evidence needed for assessing the clinical and cost-effectiveness of cell and gene therapies and how these are recognized in health technology assessments (HTA) processes.
- - A literature review analyzed 46 HTA reports on 9 products in various jurisdictions, revealing positive reactions to evidence related to rare diseases, substantial health gains, and alternative payment models; while they were critical of unvalidated endpoints, inadequate trial reporting, and uncertainty in economic estimates.
- - The findings indicate that HTA bodies have inconsistent approaches to evaluating cell and gene therapies, suggesting improvements in decision-making and additional analyses to better handle the complexities these therapies present.
Background: In this paper we discuss and present evidence on whether a generic Health Related Quality of Life (HRQoL) measurement tool, the EQ-5D-5L, captures the dimensions of quality of life (QoL) which patients consider significant.
Methods: An online survey, of individuals with a chronic condition, mainly breast cancer (BC), blood cancers (BLC), rheumatoid arthritis (RA), asthma, and rare diseases (RD) was conducted to collect data on HRQoL and important QoL aspects that respondents thought were not captured by the EQ-5D-5L. Patient organisations across 47 countries were invited to voluntarily share the survey tool with their membership network.
DIFFERENTIATION OF HEALTH-RELATED QUALITY OF LIFE OUTCOMES BETWEEN FIVE DISEASE AREAS: RESULTS FROM AN INTERNATIONAL SURVEY OF PATIENTS.
Int J Technol Assess Health Care
January 2018
Objectives: Health-related quality of life (HRQoL) data generated by generic, preference-based instruments (i.e., EQ-5D) are highly demanded in health policy decision making, because they allow for direct comparisons of HRQoL outcomes between disease areas.
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- * Findings suggest a paradigm shift in MS management is necessary, focusing on better diagnostic follow-ups and earlier use of disease-modifying treatments (DMTs).
- * The study emphasizes that these changes could lead to better clinical outcomes, enhanced quality of life, and reduced socioeconomic burdens for individuals affected by MS.
Responsiveness of the EQ-5D to clinical change: is the patient experience adequately represented?
Int J Technol Assess Health Care
January 2014
Objectives: In many economic evaluations and reimbursement decisions, quality-adjusted life-years (QALYs) are used as a measure of benefit to assess effectiveness of novel therapies, often based on the EQ-5D 3-level questionnaire. As only five dimensions of physical and mental well-being are reflected in this tool, significant aspects of the patient experience may be missed. We evaluate the use of the EQ-5D as a measurement of clinical change across a wide range of disorders from dermatological (acne) to life-threatening (metastatic cancers).
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- There is a growing focus on patient-centered health care and the need to include patients' perspectives in health technology assessments (HTA), which should inform decision-making processes. !* -
- Currently, HTA primarily relies on quantitative evidence regarding clinical and cost effectiveness, often neglecting patients' views, which are sometimes dismissed as anecdotal or biased. !* -
- To improve HTA, it's essential to gather robust evidence of patients' perspectives through rigorous social science research, and to actively engage patients at various stages of the HTA process to ensure their insights contribute to a transparent and fair deliberative process. !*