[History of the rhenish and alsacian contributions to the understanding of diabetes].

The history of diabetes mellitus is punctuated from the Egyptian Antiquity by sometimes amazingly acute clinical observations and inversely several missed opportunities on the way of the discovery of the mechanisms of the disease and of the development of its therapies.Alsace, and more generally the Rhine countries, have played a major role in this adventure, of which a crucial step has been the experimental demonstration of the role of the pancrease in the pathogenis of the disease by Oskar Minkowski and Joseph von Mering in Strasbourg in 1889.

[Recurrent facial palsy, primary Gougerot-Sjögren's syndrome and vitamin B12 deficiency].

Introduction: Differing cranial nerve involvement has been reported in the context of Gougerot-Sjögren's syndrome. Involvement of the V, III and VII nerves has been reported, the most characteristic being nerve V, notably its lower branch. Rare, well documented, cases of facial palsy have also been described.

Retrospective monocentric study of 17 patients with adult Still's disease, with special focus on liver abnormalities.

Background/aims: Adult Still's disease is one of the febrile disorders of unknown etiology, characterized by high fever, transient cutaneous rash and leukocytosis. Liver dysfunction in adult Still's disease has been described in some case reports. The objective of this study was to analyze the pattern and the frequency of liver abnormalities in a monocenter series of adult Still's disease patients.

Modern management of non-chemotherapy drug-induced agranulocytosis: a monocentric cohort study of 90 cases and review of the literature.

BACKGROUND: The present study reports a monocentric experience of 90 drug-induced agranulocytosis cases and discusses their management, in particular the role of hematopoietic growth factors. METHODS: Data from 90 patients with drug-induced agranulocytosis who met the criteria of the IAAAS group and of Bénichou and Solal-Celigny [Nouv Rev Fr Hematol 1993; 33: 257.] were retrospectively reviewed.