Characterization of lymphocyte surface markers in patients with vitiligo.

It was demonstrated that all vitiligo patients, independently of the disease stage, have a significant decrease in the total number of T cells and an elevated level of peripheral blood lymphocytes and activated natural killers (CD56). The low level of T lymphocytes is associated with the increase in the number of CD3(+)4(+)8(+) cells, which are characterized by a faster apoptosis induction. The elevated level of B lymphocytes in peripheral blood in vitiligo is due to the significant increase in the number of B cells of all the stages of differentiation, suggesting a general activation of the whole B-cell immunity.

Restoration of FAS-Mediated Apoptosis of Lymphocytes in Patients with Myocarditis by Specific Peptide Sequence of Human Alpha-Fetoprotein (AFP(13-19)).

Human alpha-fetoprotein (AFP) is capable of modulating cellular proliferative processes. A study has been made of the regulatory properties of a synthetic peptide corresponding to the part of the human AFP molecule participating in receptor interaction, the peptide consisting of seven amino acids and having an amino acid sequence LDSYQCT. The study was carried out on the lymphocytes of the peripheral blood of six patients with immune myocarditis in the period of exacerbation of the illness.

Dynamic Characteristic of Surface Phenotype of Peripheral Blood Lymphocytes in Myocarditis Patients.

A study of the expression of activated markers in peripheral blood lymphocytes makes it possible to carry out continuous monitoring of the immune system of a patient by means of a non-invasive method. This is of great importance for patients with acute myocarditis with immunopathological processes. However, there are very few papers in medical literature which are dedicated to this problem.

Immunological mechanisms of recovery from an acute stage in patients with atopic bronchial asthma.

We have conducted a comparative study of the lymphocyte surface antigens in patients with atopic bronchial asthma (ABA) in an acute stage and during clinical remission of the disease using a wide variety of monoclonal antibodies. In patients with ABA, independently of the stage of the disease, we have observed a decline in the total number of T lymphocytes due to cell reduction in both sub-populations--T helpers and cytotoxic T cells. During the acute phase of the disease a significant increase in the number of B lymphocytes at all stages of differentiation was observed.