Increased skeletal muscle phosphocreatine recovery after sub-maximal exercise is associated with increased carotid intima-media thickness.

Background: The association between skeletal muscle mitochondrial function and CVD risk in healthy subjects is unknown.

Methods: Forty subjects were evaluated for CVD risk with lipid profile, oral glucose tolerance test and measurement of carotid intima-media thickness (cIMT). Skeletal muscle mitochondrial function was determined by phosphocreatine recovery after sub-maximal exercise with (31)Phosphorous-MRS and represented as τPCr.

The relationship between reduced testosterone, stimulated growth hormone secretion and increased carotid intima-media thickness in obese men.

Objective: Obesity is associated with reduced testosterone and growth hormone (GH). However, the interrelationship between these axes and their independent contributions to cardiovascular risk is unknown. The objectives of this study were to determine (1) the association between testosterone and GH in obesity, (2) whether excess adiposity mediates this association and (3) the relative contribution of reduced testosterone and GH to increased carotid intima-media thickness (cIMT) in obesity.

Reduced growth hormone secretion is associated with increased carotid intima-media thickness in obesity.

Context: Obesity is associated with reduced GH.

Objective: The aim of the study was to determine whether reduced GH is associated with increased carotid intima-media thickness (cIMT) in obesity.

Design: A total of 102 normal-weight and obese men and women without known hypopituitarism were studied.

Carotid intimal medial thickness in human immunodeficiency virus-infected women: effects of protease inhibitor use, cardiac risk factors, and the metabolic syndrome.

Context: Little is known regarding carotid intimal medial thickness (IMT) in HIV-infected women and the risk factors for subclinical atherosclerosis in this population, including antiretroviral therapy and the metabolic syndrome.

Objective: Our objective was to assess carotid IMT in relationship to HIV status and antiretroviral therapy in HIV-infected women in comparison with healthy age- and body mass index (BMI)-matched control subjects.

Setting And Subjects: The study took place at an academic medical center and included 97 HIV-infected women compared with 86 age- and BMI-matched healthy control subjects.

Effects of obesity, body composition, and adiponectin on carotid intima-media thickness in healthy women.

Context: Increased common carotid intima-media thickness (IMT) is predictive of coronary artery disease and stroke.

Objective: In this study, we investigated common carotid IMT by obesity category in a cohort of healthy women without previously known cardiovascular disease.

Design, Setting, Participants, And Main Outcome Measures: One hundred healthy women (aged 24-59 yr) from the general community enrolled in an observational study conducted at an academic medical center participated in the study.