Publications by authors named "Jean Louis Cazin"
Article Synopsis
- * ADCs combine antibodies with cytotoxics for targeted cancer therapy and are showing promise in metastatic breast and bladder cancers, with examples like trastuzumab deruxtecan for HER2-positive breast cancer.
- * Bispecific antibodies can engage both tumor and immune cells, facilitating immune responses against cancer, with several candidates in development for conditions like lymphoma and myeloma.
Article Synopsis
- The COVID-19 pandemic has significantly affected health care for cancer patients, who are particularly vulnerable to severe complications from the virus, prompting oncologists to reassess their treatment approaches.
- This review discusses international guidelines that aim to optimize cancer care by proposing alternative treatment options that reduce the need for hospital visits, especially for immunocompromised patients.
- It also highlights the challenges related to drug interactions and adverse effects due to polypharmacy in cancer patients and presents a data board to help healthcare professionals manage drug-related issues effectively during this pandemic period.
There is currently a paucity of data on salvage intracerebrospinal fluid (intra-CSF) chemotherapy in leptomeningeal metastases (LM). This report is a single-institution experience with salvage treatment in patients with breast cancer (BC) and LM. This retrospective cohort describes 24 consecutive patients with BC selected for a second-line of treatment for LM.
View Article and Find Full Text PDFBackground/aim: Prolonged overall survival (OS) has been reported for selected patients with leptomeningeal metastases (LM). The management and treatment of such patients is poorly-described. We report our experience on breast cancer (BC)-associated LM and patients with prolonged survival.
View Article and Find Full Text PDFBackground: Plasticizers such as di(2-ethylhexyl) phthalate (DEHP) are added to polyvinyl chloride (PVC) to confer flexibility. However, DEHP is associated with reproductive disorders in humans. Because of its noncovalent bond to the PVC matrix, this plasticizer tends to leach easily.
View Article and Find Full Text PDFThe treatment of leptomeningeal metastasis is based on protocols linking systemic chemotherapies and intrathecal injections of antineoplastic agents. Since the late 1960s, cases of accidental intrathecal injections of vinca-alkaloids, which have almost always proved fatal, have been documented. The most concerned countries, supported by the WHO, have published numerous recommendations aimed at reducing this type of risk.
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