Publications by authors named "Jean Louis Abdourahim Ndiaye"
Article Synopsis
- * A study conducted in Senegal analyzed the genetic diversity of PfCyRPA in 95 malaria isolates, finding a mostly common wild type allele, with 15 identified single nucleotide polymorphisms (SNPs), mostly appearing as unique changes.
- * Structure-based modeling showed that while most SNPs have minor effects on PfCyRPA antibodies, some may significantly affect its structure or interaction with the viral protein PfRH5, providing insights for future malaria vaccine design.
Article Synopsis
- Despite progress in Senegal, three southeastern regions still face a high burden of malaria, particularly among pregnant women, highlighting a gap in recent studies on this issue.
- In a 2019 study, 877 pregnant women at 11 health clinics were tested for malaria, revealing a prevalence of 48% among those attending scheduled visits, and a staggering 86% among those showing signs of malaria.
- The study found that the rapid diagnostic tests (RDT) missed many asymptomatic infections, indicating that more effective prevention methods are needed to address the high prevalence of malaria in pregnant women.
Malaria parasite carriage before and two years after the implementation of seasonal malaria chemoprevention: a case study of the Saraya health district, southern Senegal.
Wellcome Open Res
October 2022
Seasonal malaria chemoprevention (SMC) has been adopted and implemented in the southern regions of Senegal in children aged between three and 120 months since 2013. Scaling up this strategy requires its evaluation to assess the impact. This study was carried out to determine the dynamics of carriage before and after two years of SMC implementation.
View Article and Find Full Text PDFEffectiveness of seasonal malaria chemoprevention administered in a mass campaign in the Kedougou region of Senegal in 2016: a case-control study.
Wellcome Open Res
April 2023
Seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine plus amodiaquine (SPAQ) is a malaria prevention strategy recommended since 2012 by the World Health Organization (WHO) for children under 5 years. In Senegal, the scaling up of SMC started in 2013 in the south-eastern regions of the country with an extension of the target to 10 years old children. The scaling up of SMC requires regular evaluation of the strategy as recommended by the WHO.
View Article and Find Full Text PDFKnowledge, attitudes and practices (KAP) to assess the impact of school children's awareness of malaria using the MOSKI KIT® tool: study case of some Dakar schools in Senegal.
Malar J
July 2021
Background: MOSKI KIT® is a fun tool designed to interest children for prevention and management of malaria. This study was carried out with the objective to assess the short- and long-term impacts of this tool on the knowledge, attitudes, and practices of school children, and on the transmission of the knowledge received at the household level as well.
Method: The study took place in elementary schools in the city centre (with relatively low endemicity) and in the Niayes area (at high risk of anopheline and malaria) in the Dakar region of Senegal.
Evidence that seasonal malaria chemoprevention with SPAQ influences blood and pre-erythrocytic stage antibody responses of Plasmodium falciparum infections in Niger.
Malar J
January 2021
Background: In endemic areas, children develop slowly and naturally anti-Plasmodium antibodies and become semi-immune. Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine + amodiaquine (SPAQ) is a new strategy to reduce malaria morbidity in West African young children. However, SMC may impact on the natural acquisition of anti-Plasmodium immunity.
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