Publications by authors named "Jean Laurent Takombe"

Background: Sub-Saharan Africa (SSA) faces the highest rate of hypertension worldwide. The high burden of elevated blood pressure (BP) in black people has been emphasized. Guidelines recommend two or more antihypertensive medications to achieve a BP control.

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Background: Use of traditional medicine (TM) is widespread in sub-Saharan Africa as a treatment option for a wide range of disease. We aimed to describe main characteristics of TM users and estimate the association of TM use with control of hypertension.

Methods: We used data on 2128 hypertensive patients of a cross-sectional study (convenience sampling), who attended cardiology departments of 12 sub-Saharan African countries (Benin, Cameroon, Congo, Democratic Republic of the Congo, Gabon, Guinea, Côte d'Ivoire, Mauritania, Mozambique, Niger, Senegal, Togo).

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Objective: In Africa, the number of patients with hypertension is expected to reach 216.8 million by 2030. Large-scale data on antihypertensive medications used in Sub-Saharan Africa (SSA) are scarce.

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Article Synopsis
  • * A post hoc analysis explored the drug samples and packaging, discovering that captopril's dosage was significantly affected by the type of blister packaging used, specifically in terms of humidity protection.
  • * The study emphasizes the importance of proper packaging materials to ensure drug quality and mitigate risks related to exposure and circulation of medications in those countries.
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Many parts of the developing world, especially Sub-Saharan Africa, completely lack access to cardiac pacing. The authors initiated a multinational program to implement cardiac pacing in 14 countries in Sub-Saharan Africa (1996 to 2018), aiming to eventually build self-sustainable capacity in each country. This was based on an "on-site training" approach of performing procedures locally and educating local health care teams to work within resource-limited settings, with prospective evaluation of the program.

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Introduction: Over the past few decades, the prevalence of hypertension has dramatically increased in Sub-Saharan Africa. Poor adherence has been identified as a major cause of failure to control hypertension. Scarce data are available in Africa.

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Objective: Hypertension results in more deaths than any other risk factor and has been on the rise in sub-Saharan Africa over the past few decades. Generic drugs have helped improve accessibility and affordability of antihypertensive therapy in developing countries. However, assessment of quality standards of these products is important.

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Article Synopsis
  • A study was conducted to assess the quality of seven common cardiovascular medications across ten Sub-Saharan African countries, focusing on the risks of poor quality and counterfeit drugs.
  • The research involved collecting 3,468 samples from both licensed pharmacies and unlicensed street markets between 2012 and 2014, using advanced laboratory methods to analyze the active ingredients.
  • The findings revealed that 16.3% of tested samples were of poor quality, with significantly higher rates observed in certain drugs and those produced in Asia, particularly in street markets where the rate soared to 50%.
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