Mesh-independent damage model for trabecular bone fracture simulation and experimental validation.

We propose in this study a two-dimensional constitutive model for trabecular bone combining continuum damage with embedded strong discontinuity. The model is capable of describing the three failure phases of trabecular bone tissue which is considered herein as a quasi-brittle material with strains and rotations assumed to be small and without viscous, thermal or other non-mechanical effects. The finite element implementation of the present model uses constant strain triangle (CST) elements.

Investigating the Effect of Aging on the Viscosity of Tendon Fascicles and Fibers.

In the current work, we investigate the effect of aging on the viscosity of tendon subunits. To that scope, we make use of experimental relaxation curves of healthy and aged tendon fascicles and fibers, upon which we identify the viscosity parameters characterizing the time-dependent behavior of each tendon subunit. We subsequently combine the obtained results with analytical viscoelastic homogenization analysis methods to extract information on the effective viscous contribution of the embedding matrix substance at the fiber scale.

Exploiting Viscoelastic Experimental Observations and Numerical Simulations to Infer Biomimetic Artificial Tendon Fiber Designs.

Designing biomimetic artificial tendons requires a thorough, data-based understanding of the tendon's inner material properties. The current work exploits viscoelastic experimental observations at the tendon fascicle scale, making use of mechanical and data analysis methods. More specifically, based on reported elastic, volumetric and relaxation fascicle scale properties, we infer most probable, mechanically compatible material attributes at the fiber scale.

An Attempt to Predict the Preferential Cellular Orientation in Any Complex Mechanical Environment.

Cells respond to their mechanical environment in different ways: while their response in terms of differentiation and proliferation has been widely studied, the question of the direction in which cells align when subject to a complex mechanical loading in a 3D environment is still widely open. In the present paper, we formulate the hypothesis that the cells orientate in the direction of unitary stretch computed from the right Cauchy-Green tensor in a given mechanical environment. The implications of this hypothesis are studied in different simple cases corresponding to either the available in vitro experimental data or physiological conditions, starting from finite element analysis results to computed preferential cellular orientation.

A two scale modeling and computational framework for vibration-induced Raynaud syndrome.

Hand-Arm Vibration syndrome (HAVS), usually caused by long-term use of hand-held power tools, can in certain manifestations alter the peripheral blood circulation in the hand-arm region. HAVS typically occurs after exposure to cold, causing an abnormally strong vasoconstriction of blood vessels. A pathoanatomical mechanism suggests that a reduction of the lumen of the blood vessels in VWF (Vibration White Finger) subjects, due to either hypertrophy or thickening of the vessel wall, may be at the origin of the disease.

Identification of couple-stress moduli of vertebral trabecular bone based on the 3D internal architectures.

The purpose of this paper is to develop a homogeneous, orthotropic couple-stress continuum model as a substitute of the 3D periodic heterogeneous cellular solid model of vertebral trabecular bone. Vertebral trabecular bone is modeled as a porous material with an idealized periodic structure made of 3D open cubic cells, which is effectively orthotropic. The chosen architecture is based on studies of samples taken from the central part of vertebral bodies.

Predictive model of the prostate motion in the context of radiotherapy: A biomechanical approach relying on urodynamic data and mechanical testing.

In this paper, a biomechanical approach relying on urodynamic data and mechanical tests is proposed for an accurate prediction of the motion of the pelvic organs in the context of the prostate radiotherapy. As a first step, an experimental protocol is elaborated to characterize the mechanical properties of the bladder and rectum wall tissues; uniaxial tensile tests are performed on porcine substrates. In a second step, the parameters of Ogden-type hyperelastic constitutive models are identified; their relevance in the context of the implementation of a human biomechanical model is verified by means of preliminary Finite Elements (FE) simulations against human urodynamic data.

Mechanical behaviour of a fibrous scaffold for ligament tissue engineering: finite elements analysis vs. X-ray tomography imaging.

The use of biodegradable scaffolds seeded with cells in order to regenerate functional tissue-engineered substitutes offers interesting alternative to common medical approaches for ligament repair. Particularly, finite element (FE) method enables the ability to predict and optimise both the macroscopic behaviour of these scaffolds and the local mechanic signals that control the cell activity. In this study, we investigate the ability of a dedicated FE code to predict the geometrical evolution of a new braided and biodegradable polymer scaffold for ligament tissue engineering by comparing scaffold geometries issued from FE simulations and from X-ray tomographic imaging during a tensile test.

A multilayer braided scaffold for Anterior Cruciate Ligament: mechanical modeling at the fiber scale.

An adapted scaffold for Anterior Cruciate Ligament (ACL) tissue engineering must match biological, morphological and biomechanical requirements. Computer-aided tissue engineering consists of finding the most appropriate scaffold regarding a specific application by using numerical tools. In the present study, the biomechanical behavior of a new multilayer braided scaffold adapted to computer-aided tissue engineering is computed by using a dedicated Finite Element (FE) code.

Morphological characterization of a novel scaffold for anterior cruciate ligament tissue engineering.

Tissue engineering offers an interesting alternative to current anterior cruciate ligament (ACL) surgeries. Indeed, a tissue-engineered solution could ideally overcome the long-term complications due to actual ACL reconstruction by being gradually replaced by biological tissue. Key requirements concerning the ideal scaffold for ligament tissue engineering are numerous and concern its mechanical properties, biochemical nature, and morphology.

A stochastic model of cell aggregation under planar flow in the dilute regime.

Models of the adhesion of a population of cells in a plane flow are developed, considering the dilute regime. Cells considered as rigid punctual entities are virtually injected at regular times within a plane channel limited by two fixed planes. The pressure profile is supposed to be triangular (constant gradient), in accordance with the assumptions of a Poiseuille flow.

Finite element simulation of interactions between pelvic organs: predictive model of the prostate motion in the context of radiotherapy.

The setting up of predictive models of the pelvic organ motion and deformation may prove an efficient tool in the framework of prostate cancer radiotherapy, in order to deliver doses more accurately and efficiently to the clinical target volume (CTV). A finite element (FE) model of the prostate, rectum and bladder motion has been developed, investigating more specifically the influence of the rectum and bladder repletions on the gland motion. The required organ geometries are obtained after processing the computed tomography (CT) images, using specific softwares.

Local modeling of the rolling phenomenon in the cell adhesion kinetics: A probabilistic approach.

Cell adhesion plays an important role in biology: essentially with regard to immunizing defence and the transport of medicinal substances toward specific zones. The focus is here on the mechanical description of adhesion kinetics, in terms of the failure and creation of connections during the rolling phenomenon. Hence, we consider the case of a single cell, which is linked to a rigid substratum.