Publications by authors named "Jean F Legare"
Background: Current intensive care unit physician-staffing (IPS) models for postoperative cardiac surgery have not been previously investigated in Canada. The purpose of this study was to determine current IPS models at 2 time points and describe the evolution of Canadian cardiac surgery IPS models.
Methods: A survey of 32 Canadian cardiovascular intensive care units (CVICUs) was undertaken in 2012 and 2017 to determine IPS models of care during "daytime" and "after-hours" in each unit.
Background: Transvenous lead extraction can have serious adverse events, such as cardiac or vascular perforation. Risk factors have not been well characterized.
Objective: The purpose of this study was to identify factors associated with perforation and death, and to characterize lead extraction in a large contemporary population.
Article Synopsis
- Predicting post-operative complications in obese cardiac surgery patients is complicated due to long-term metabolic issues linked to obesity, particularly involving branched-chain amino acids (BCAAs).
- The study examines whether changes in BCAA metabolism can be used as predictors for adverse outcomes in these patients, analyzing blood and tissue samples from various BMI categories.
- Findings reveal that while intramyocellular BCAAs rise with BMI, there's decreased activity of BCAA catabolic enzymes in the adipose tissue of severely obese individuals, indicating a connection between BCAA metabolism, metabolic dysfunction, and recovery after surgery.
Background: Much has been published about the effect of obesity on adverse outcomes after cardiac operations, yet little is known regarding the effect of obesity on intensive care unit (ICU) resource utilization. This study examined the effect of obesity on ICU resource utilization after cardiac operations.
Methods: All patients with a body mass index (BMI) of 18.
Impaired cardiac metabolism in the obese and diabetic heart leads to glucolipotoxicity and ensuing cardiomyopathy. Glucolipotoxicity causes cardiomyocyte injury by increasing energy insufficiency, impairing proteasomal-mediated protein degradation and inducing apoptosis. Proteasome-evading proteins are degraded by autophagy in the lysosome, whose metabolism and function are regulated by master regulator transcription factor EB (TFEB).
View Article and Find Full Text PDFBackground: Macrophages (MΦ) are functionally diverse and dynamic. Until recently, cardiac MΦ were assumed to be monocyte derived; however, resident cardiac MΦ (rCMΦ), present at baseline, were identified in myocardia and have been implicated in cardiac healing. Previously, we demonstrated that CCR2(-/-) mice are protected from myocardial fibrosis - an observation initially attributed to changes in infiltrating monocytes.
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