Publications by authors named "Jean Del Grande"
Article Synopsis
- The study aimed to identify typical clinical and radiological profiles of primary low-grade parotid cancers to improve treatment strategies.
- A retrospective analysis of 57 patients was conducted, reviewing MRI and histopathology results to identify prognostic factors.
- While several positive prognostic factors were identified, the study concluded that a reliable clinical and radiological profile for low-grade cancers could not be established, limiting the ability to tailor more conservative surgical approaches.
Purpose: Parotid pleomorphic adenomas present a risk of recurrence, higher when the tumour is a hypocellular subtype. The aim of the study was to determine whether it is possible to characterize this histological subtype with diffusion and perfusion sequences of the preoperative MRI.
Methods: This retrospective study included 97 patients operated between 2010 and 2020.
Article Synopsis
- The study aimed to enhance the diagnosis of parotid gland tumors by developing automated decision-tree models using multiparametric MRI data, comparing their effectiveness to traditional morphological sequences.
- A total of 206 MRIs were analyzed to build predictive models, which included various MRI parameters, showing a significant improvement in diagnostic performance for most tumor types when multiparametric analysis was used.
- Key findings indicated that the ADCmean and the mean extracellular-extravascular space coefficient were the most effective parameters for distinguishing between different histological types of tumors, leading to better non-invasive diagnostic outcomes.
Pancreatic adenocarcinoma (PDAC) is a dismal disease. The lack of specific symptoms still leads to a delay in diagnosis followed by death within months for most patients. Exon 11 of the bile salt-dependent lipase (BSDL) gene encoding variable number of tandem repeated (VNTR) sequences has been involved in pancreatic pathologies.
View Article and Find Full Text PDFIntroduction: Laryngeal tuberculosis is a rare and often misdiagnosed disease. Its diagnosis is based on the association of a laryngeal lesion and the microbiological detection of Mycobacterium tuberculosis. Stool cultures have recently been described as a useful tool in the diagnosis of atypical forms of tuberculosis.
View Article and Find Full Text PDFBackground: No predictive marker has been yet identified for bevacizumab which is widely used in metastatic colorectal cancer.
Aims: Evaluate impact of single nucleotide polymorphisms involved in Vascular Endothelial Growth Factor pathway on efficacy and tolerance of bevacizumab.
Methods: We retrospectively included patients who were treated with bevacizumab-based chemotherapy for metastatic colorectal cancer, and for whom a deoxyribonucleic acid sample was available.
Natural history of anal intraepithelial neoplasia and anal cancer is not fully understood. Factors associated with cytological abnormalities and predictors of progression to high-grade anal intraepithelial neoplasia still deserve investigation. The aim of this cross-sectional study was to assess the prevalence of HPV types, the relationship between HPV genotypes, HPV 16/18 viral load and cytological abnormalities in male and female HIV-infected patients.
View Article and Find Full Text PDFArticle Synopsis
- - Sarcoidosis is a complex disease that causes granulomas (inflammation) and often affects the spleen, leading to either overall enlargement or distinct nodules.
- - A case study describes a 37-year-old woman with isolated splenic sarcoidosis that looked like cancer when viewed through ultrasound and MRI imaging.
- - Recognizing this unusual appearance in imaging can help avoid unnecessary surgeries like spleen removal (splenectomy).