Publications by authors named "Jean Cyr"
Article Synopsis
- HPV vaccination is crucial for preventing cervical cancer in adolescent girls, but many are under-vaccinated due to cost and logistics.
- Research indicates that a single dose of the HPV vaccine may be as effective as two doses, which led to a large trial comparing the effectiveness of one versus two doses of bivalent and nonavalent vaccines.
- The ESCUDDO trial, involving over 20,000 girls in Costa Rica, aims to evaluate vaccine efficacy through follow-up visits and comparisons with unvaccinated women.
Article Synopsis
- In 2016, the cancer registry community began directly assigning the components of cancer stage (T, N, M) due to frequent unavailability in medical records.
- A field study involving 280 cases across various cancer types found that pathologic TNM data was more accessible than clinical data, with only about 20% of clinical elements available.
- The study highlighted a significant need for improved training for registrars, as there was considerable variability in agreement between participant responses and assigned TNM data across different cancer types.
We report the rationale, design, methods and details of participation of a community-based, double-blind, randomized clinical trial of an HPV 16 and 18 vaccine conducted in two provinces of Costa Rica to investigate the efficacy and population impact of the vaccine in the prevention of cervical cancer precursors. More than 24,000 women between 18 and 25 years of age were invited to participate and pre-screened for eligibility, with recruitment of 7466 women (30% of those pre-screened, 59% of those eligible) who were randomized to receive 3 doses of the HPV vaccine or hepatitis A vaccine as control. A complex protocol of data and specimen collection was applied, including an interview, pelvic exam for sexually active women, blood for serology and cell-mediated immunity, cervical secretions for local immunity and cells for HPV, Chlamydia trachomatis and gonorrhea testing.
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