Publications by authors named "Jean Claude Beer"
Article Synopsis
- Acute infections are common triggers for myocardial infarction (MI), but it's unclear if percutaneous coronary intervention (PCI) improves outcomes for those with post-infectious MI.
- In a study involving 4,573 MI patients, 476 had acute infections, and among those with significant coronary stenosis, only 195 received PCI.
- After analyzing the data, researchers found no significant differences in in-hospital or one-year mortality rates between patients who received PCI and those who did not, suggesting that PCI may not enhance prognosis in these cases.
Article Synopsis
- A prospective study was conducted to determine the optimal systolic blood pressure in elderly patients during the first 48 hours after an acute myocardial infarction and its impact on cardiovascular mortality.
- The study included 814 patients over 75 years old and found that those with an average systolic blood pressure below 125 mm Hg had a significantly higher risk of cardiovascular death within one year.
- Low systolic blood pressure emerged as a strong independent predictor of 1-year cardiovascular mortality, indicating the importance of early blood pressure measurement for risk assessment in elderly patients.
Prevalence, risk factor burden, and severity of coronary artery disease in patients with heterozygous familial hypercholesterolemia hospitalized for an acute myocardial infarction: Data from the French RICO survey.
J Clin Lipidol
June 2020
Article Synopsis
- This study investigates the prevalence and severity of familial hypercholesterolemia (FH) among French patients hospitalized for acute myocardial infarction (MI) over a 16-year period.
- Among 11,624 patients, 2.1% were diagnosed with "probable/definite" FH, who were notably younger and had different health profiles compared to those with "unlikely" FH.
- Findings revealed that patients with FH experienced more extensive and severe coronary artery disease, in addition to highlighting the low usage rates of preventive lipid-lowering treatments like statins and ezetimibe.
Aims: To derive and validate a readily useable risk score to identify patients at high-risk of in-hospital ST-segment elevation myocardial infarction (STEMI)-related cardiogenic shock (CS).
Methods And Results: In all, 6838 patients without CS on admission and treated by primary percutaneous coronary intervention (pPCI), included in the Observatoire Régional Breton sur l'Infarctus (ORBI), served as a derivation cohort, and 2208 patients included in the obseRvatoire des Infarctus de Côte-d'Or (RICO) constituted the external validation cohort. Stepwise multivariable logistic regression was used to build the score.
Background: Red blood cell transfusion benefit during acute myocardial infarction remains unclear in the elderly. We aimed to assess the transfusion impact on 1-year mortality in acute myocardial infarction patients aged ≥65 years, according to their age and hemoglobin nadir.
Methods: We included 3316 consecutive patients with acute myocardial infarction aged ≥65 years from the "obseRvatoire des Infarctus de Côte d'Or" (RICO) survey.
Atrial fibrillation (AF) is the most frequent heart rhythm disorder in the general population and contributes not only to a major deterioration in quality of life but also to an increase in cardiovascular morbimortality. The onset of AF in the acute phase of myocardial infarction (MI) is a major event that can jeopardize the prognosis of patients in the short-, medium- and long-term, and is a powerful predictor of a poor prognosis after MI. The suspected mechanism underlying the excess mortality is the drop in coronary flow linked to the acceleration and arrhythmic nature of the left ventricular contractions, which reduce the left ventricular ejection fraction.
View Article and Find Full Text PDFBackground: Atrial fibrillation (AF), whether silent or symptomatic, is a frequent and severe complication of acute myocardial infarction (AMI). Asymmetric dimethylarginine (ADMA), an endogenous eNOS inhibitor, is a risk factor for endothelial dysfunction. We addressed the relationship between ADMA plasma levels and AF occurrence in AMI.
View Article and Find Full Text PDFIntroduction: In secondary prevention (SP) of coronary artery disease (CAD), in particular after an acute myocardial infarction (MI), a better knowledge and self-management by the patient may have various supports. The Log book (LB) for CAD patients in Côte d'Or, was created in 2010 by a multidisciplinary team of healthcare professionals of Côte d'Or, from a regional care network. This pilot study evaluated LB as novel support for SP after acute MI.
View Article and Find Full Text PDFBackground: Silent atrial fibrillation (AF), assessed by continuous ECG monitoring (CEM), has recently been shown to be common in acute myocardial infarction (AMI), and associated with higher hospital mortality. However, the long-term prognosis is still unknown. We aimed to assess 1-year prognosis in patients experiencing silent AF in AMI.
View Article and Find Full Text PDFBackground: Silent atrial fibrillation (AF) has been suggested to be frequent after acute myocardial infarction (MI). Continuous ECG monitoring (CEM) has been shown to improve AF screening in patients at risk of stroke.
Objectives: We aimed to assess the incidence and prognosis of silent AF in patients with acute MI.
Background: The presence of pre-infarction angina (PIA) has been shown to confer cardioprotection after ST-segment elevation myocardial infarction (STEMI). However, the clinical impact of PIA in non-ST-segment elevation myocardial infarction (NSTEMI) remains to be determined.
Methods And Results: From the obseRvatoire des Infarctus de Côte d'Or (RICO) survey, 1541 consecutive patients admitted in intensive care unit with a first NSTEMI were included.
Background: Myocardial infarction with ST-segment elevation (STEMI) is a medical emergency requiring specific management, with the main aim of achieving reperfusion as quickly as possible. Guidelines from medical societies have defined optimal management, with proven efficacy on morbi-mortality.
Aims: Our study aimed to evaluate trends in practices between 2002 and 2010 in the emergency management of STEMI in a single French department, namely Cote d'Or.
Objective: The aim of this study was to analyze the impact of diverting off-hour calls to Emergency Medical Dispatch Centers (EMDC) on time delays and revascularization procedures for patients with ST-segment elevation myocardial infarction (STEMI) in a French region.
Methods: A total of 3376 consecutive patients admitted for acute STEMI were included from the RICO survey (a French regional survey for acute myocardial infarction). Patients were retrospectively classified into two groups: before (2001-2004) and after EMDC (2005-2008) implementation and followed up for mortality as primary outcomes.
Objectives: To compare 2 cardiac magnetic resonance (CMR) techniques for the evaluation of the prognostic significance of microvascular damage after non ST-segment elevation myocardial infarction (NSTEMI).
Materials And Methods: CMR was performed at 3T in 61 patients within the week following their first NSTEMI. A first-pass saturation-recovery gradient-echo perfusion sequence was started during the infusion of contrast material to evaluate the extent of microvascular obstruction (MO) during the first 2 minutes after injection (MO(<2 min)) and between 3 and 5 minutes thereafter (MO(3 min), MO(4 min), MO(5 min)).
The aim of this study was to compare the prognostic significance of microvascular obstruction (MO) and persistent microvascular obstruction (PMO) as assessed by cardiac magnetic resonance (CMR) in patients with acute myocardial infarction (AMI). CMR was performed in 184 patients within the week following successfully reperfused first AMI. First-pass images were performed to evaluate extent of MO and late gadolinium-enhanced images to assess PMO and infarct size (IS).
View Article and Find Full Text PDFBackground: An elevated body mass index (BMI) has been reported to be associated with a lower rate of death after acute myocardial infarction (AMI). However, waist circumference (WC) may be a better marker of cardiovascular risk than BMI. We used data from a contemporary French population-based cohort of patients with AMI to analyze the impact of WC and BMI on death rates.
View Article and Find Full Text PDFObjective: Asymmetrical dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide (NO) synthases. From a prospective cohort of patients with acute myocardial infarction (MI), we aimed to analyze the predictive value of circulating ADMA concentrations on prognosis.
Methods And Results: Blood samples from 249 consecutive patients hospitalized for acute MI <24 hours were taken on admission.
Background: Randomized studies have shown a reduction in cardiovascular events associated with low doses of statin among hypertensive patients at only moderate cardiovascular risk. The hypothesis of the present study was that statin therapy initiated during hospitalization could improve the long-term outcome after acute myocardial infarction (MI) in hypertensive patients.
Methods: From the French regional obserRvatoire des Infarctus de Côte d'Or (RICO) survey, 1076 patients with a history of hypertension, surviving acute MI were included.
Background: We aimed to investigate the determinants and outcomes of multiple complex lesions (MCLs) on coronary angiography in patients with an acute myocardial infarction.
Methods: One thousand one hundred fifty-two consecutive nonselected myocardial infarction patients who underwent coronary angiography within 24 hours after admission were analyzed. A complex lesion was defined by the presence of thrombus, ulceration, irregular plaque, and flow impairment.
Objective: The prognosis of patients with acute myocardial infarction (MI), according to the new criteria for impaired fasting glucose (IFG) (FG 100-126 mg/dl), has not been evaluated.
Research Design And Methods: A total of 2353 patients with acute MI and surviving at d 5 after admission were analyzed for short-term morbidity and mortality. FG was obtained at d 4 and 5.
Hyperglycemia has been shown to be a powerful predictor of worse outcome after ST-segment-elevation myocardial infarction (STEMI), which could be related to impaired myocardial reperfusion. This study investigated the association between hyperglycemia and ST-segment resolution (STR) after thrombolysis. From the French regional Observatoire des Infarctus de Côte-d'Or survey, admission glucose in 371 patients with STEMIs who were treated by lysis<12 hours was analyzed.
View Article and Find Full Text PDFBackground: Acute myocardial infarction (AMI) in elderly patients is often unrecognized and associated with poor prognosis.
Objectives: To investigate management and efficacy of reperfusion therapy to the elderly patients with AMI.
Methods: From the January 1, 2001 to October 31, 2002, 964 patients with AMI were included in the French regional RICO survey.
Article Synopsis
- The study examined the prevalence and impact of metabolic syndrome on patients who experienced acute myocardial infarction (AMI), finding that nearly half (46%) of the 633 patients met the criteria for metabolic syndrome.
- Patients with metabolic syndrome were generally older, more likely to be women, and showed higher in-hospital mortality and severe heart failure rates compared to those without the syndrome.
- Hyperglycemia was identified as the strongest predictor of severe heart failure among the components of metabolic syndrome, highlighting its significance in patient outcomes after AMI.
Article Synopsis
- A study examined how plasma N-terminal pro-brain natriuretic peptide (Nt-pro-BNP) levels are linked to short-term outcomes in diabetic patients after a myocardial infarction (MI).
- The results showed significantly higher Nt-pro-BNP levels in diabetic patients compared to non-diabetic patients, which remained significant even after accounting for various health factors.
- High Nt-pro-BNP levels were associated with increased hospital mortality and cardiogenic shock in diabetic patients, highlighting its potential as an important marker for assessing risk after MI.