Publications by authors named "Jean Christophe Pont"
Article Synopsis
- A systematic review and meta-analysis was conducted to understand the impact of paternal age on live birth rates (LBR) in egg donation cycles, given the rising trend of delayed parenthood globally.
- The analysis included 11 studies with over 10,500 egg donation cycles and found a significant decrease in LBR as paternal age increased, indicating that older fathers may have slightly lower success rates in IVF.
- Despite the findings showing a decline in live birth rates with older paternal age, no specific age threshold was determined, highlighting the need for further research and the importance of this information for men considering having children later in life.
Cyclic fertilin peptide (cFEE: phenylalanine, glutamic acid; glutamic acid) improves gamete interaction in humans. We investigate whether it could be via improvement of sperm movement parameters and their mitochondrial ATP production. Sperm movement parameters were studied using computer-assisted sperm analysis (CASA) in sperm samples from 38 patients with normal sperm in medium supplemented with cyclic fertilin against a control group.
View Article and Find Full Text PDFFor nonobstructive azoospermic (NOA) patients with a normal karyotype or for Klinefelter syndrome (47,XXY) patients, intracytoplasmic sperm injection is associated with an increased aneuploidy risk in offspring. We examined testicular cells from patients with different azoospermia etiologies to determine the origin of the aneuploid spermatozoa. The incidence of chromosome abnormalities was investigated in all types of azoospermia.
View Article and Find Full Text PDFObjective: To assess the effect of leukocytospermia on assisted reproductive technology outcomes.
Design: Retrospective analysis.
Setting: University laboratory.
Objective: To report the level of leukocytospermia in fertile donors' semen. Surprisingly, seminal leukocytes protect fertilization properties of sperm and are associated with normal or improved assisted reproductive technology outcomes in infertility patients. This raises the question of whether leukocytospermia exists in fertile men as well.
View Article and Find Full Text PDFObjective(s): We aimed to evaluate and compare the embryo quality at early cleavage stages using different oils overlaying media to culture human embryos during IVF/ICSI treatments.
Study Design: A total of 500 IVF/ICSI treatments from 500 women were analyzed in a prospective randomized study. Oocytes/embryos were treated into microdroplets of appropriate media overlaid with (i) Mineral Oil (CryoBioSystem, L'Aigle, France) (group 1, n=129), (ii) Liquid Paraffin (Medicult, Lyon, France) (group 2, n=126), (iii) Nidoil (Nidacon International, Guthenburg, Sweden) (group 3, n=126) and (iv) Ovoil (Vitrolife, Kungsbacka, Sweden) (group 4, n=119).