Publications by authors named "Jean Christophe Ferre"
Article Synopsis
- The study investigates the effectiveness of amide proton transfer-weighted imaging (APTwi) for differentiating between brain tumors and tumor mimics in a clinical setting, analyzing data from 156 patients.
- Results revealed that the APT signal intensity (APT-SI) is significantly higher in tumors compared to tumor mimics, particularly in high-grade gliomas and specific tumor subtypes like mesenchymal tumors.
- The findings suggest that while high APT-SI is more common in aggressive tumors, it can also appear in certain low-grade tumors and tumor mimics, indicating a potential limitation in using APTwi as a definitive diagnostic tool.
Background And Objectives: The dynamics of microstructural spinal cord (SC) damage and repair in people with multiple sclerosis (pwMS) and their clinical relevance have yet to be explored. We set out to describe patient-specific profiles of microstructural SC damage and change during the first year after MS diagnosis and to investigate their associations with disability and SC atrophy at 5 years.
Methods: We performed a longitudinal monocentric cohort study among patients with relapsing-remitting MS: first relapse <1 year, no relapse <1 month, and high initial severity on MRI (>9 T2 lesions on brain MRI and/or initial myelitis).
Background: Mechanical thrombectomy (MT) is an effective treatment for acute ischemic stroke from large vessel occlusion (LVO). While embolization to a new territory (ENT) after MT is well-documented, data on embolization in the same distal territory (EDT) are limited. Achieving modified Treatment In Cerebral Infarction (mTICI) 3 reperfusion presents significant clinical benefits over mTICI 2b/2c, necessitating strategies to reduce both ENT and EDT.
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- The study aimed to track the outcomes of patients with brain arteriovenous malformations (AVMs) who were managed conservatively, revealing key statistics on related morbidity and mortality over a 10-year period.
- Out of 1010 patients initially recruited, 434 were analyzed, with a majority having unruptured low-grade AVMs, demonstrating a 5% occurrence of serious outcomes and a higher risk in those with a history of rupture or older age.
- During the follow-up of approximately 3.2 years, 8% of patients experienced major intracranial hemorrhages, highlighting the ongoing risks associated with conservative management of AVMs.
Article Synopsis
- The ACET study investigates the occurrence of thromboembolic events (TEEs) after endovascular treatment (EVT) for unruptured intracranial aneurysms using diffusion-weighted imaging (DWI) MRI, aiming to standardize the evaluation of these complications.
- Out of 233 patients treated across six centers, 58.8% exhibited DWI lesions post-procedure, with significantly higher rates in those undergoing techniques involving device placement like balloon-assisted coiling and stent-assisted coiling.
- The findings suggest that the EVT techniques themselves notably influence the likelihood of DWI lesions, highlighting the need for careful consideration of the methods adopted in EVT procedures.*
Background: Automatic tools for detecting new lesions in patients with MS between two MRI scans are now available to clinicians. They have been assessed from the radiologist's point of view, but their impact on the therapeutic strategies that neurologists offer their patients has not yet been documented.
Objectives: To compare neurologist's decisions according to whether a lesion detection support system had been used and describe variability between neurologists on decision-making for the same clinical cases.
Background: Non-ischemic cerebral enhancing (NICE) lesions following aneurysm endovascular therapy are exceptionally rare, with unknown longitudinal evolution.
Objective: To evaluate the radiological behavior of individual NICE lesions over time.
Methods: Patients included in a retrospective national multicentric inception cohort were analyzed.
Objective: The Fluid And White matter Suppression (FLAWS) MRI sequence provides multiple T1-weighted contrasts of the brain in a single acquisition. However, the FLAWS acquisition time is approximately 8 min with a standard GRAPPA 3 acceleration factor at 3 T. This study aims at reducing the FLAWS acquisition time by providing a new sequence optimization based on a Cartesian phyllotaxis k-space undersampling and a compressed sensing (CS) reconstruction.
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- * The majority of the patients had severe COVID-19, with 90% showing abnormal ASL perfusion, particularly hypoperfusion in the temporal poles and frontal lobes, even if traditional MRI scans appeared normal.
- * The findings highlight that over 80% of these patients exhibited significant brain perfusion deficits, suggesting that neurological complications in COVID-19 can occur independently of visible lesions on standard MRI scans.
Head-CT-scanning is a cornerstone procedure during the management of patients admitted for acute brain injury (ABI) in intensive care unit (ICU). But intrahospital transfer for these procedure is known to increase the rate of severe adverse events potentially worsening the brain injuries. Portable head-CT (pCTH) may facilitate pCTH performance in safer conditions for the patients avoiding transfer out of the ICU.
View Article and Find Full Text PDFBackground: The CLinical Assessment of WEB device in Ruptured aneurYSms (CLARYS) study has shown that the endovascular treatment of ruptured bifurcation aneurysms with the Woven EndoBridge (WEB) is safe and effective and provides protection against rebleeding at 1 month and 1 year. The 12-month angiographic follow-up is an important endpoint of the study.
Methods: The CLARYS study is a prospective multicenter study conducted in 13 European centers.
Impact of COVID-19 on thrombus composition and response to thrombolysis: Insights from a monocentric cohort population of COVID-19 patients with acute ischemic stroke.
J Thromb Haemost
April 2022
Article Synopsis
- COVID-19 patients with acute ischemic stroke (AIS) exhibit thrombi that are rich in neutrophils and contain neutrophil extracellular traps (NETs), but lack the virus's spike protein.
- A study comparing AIS thrombi from COVID-19 and non-COVID-19 patients found that both types displayed similar resistance to thrombolysis when treated with tissue-type plasminogen (tPA).
- Adding DNase 1 enhanced the thrombolytic process for both groups, suggesting that COVID-19 does not affect NET content or the thrombi's resistance to fibrinolysis, which could help in treating such patients.
Background: In neurovascular treatment planning, endovascular devices to manage complex intracranial aneurysms requiring intervention are often selected based on conventional measurements and interventional neuroradiologist experience. A recently developed technology allows a patient-specific 3D-printed model to mimic the navigation experience. The goal of this study was to assess the effect of pre-procedure 3D simulation on procedural and clinical outcomes for wide-neck aneurysm embolization.
View Article and Find Full Text PDFImpaired memory is a hallmark of prodromal Alzheimer's disease (AD). Prior knowledge associated with the memoranda improves memory in healthy individuals, but we ignore whether the same occurs in early AD. We used functional MRI to investigate whether prior knowledge enhances memory encoding in early AD, and whether the nature of this prior knowledge matters.
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- Over the past decade, the number of approved drugs for treating Multiple Sclerosis (MS) has expanded from 3 to 10, allowing for more personalized treatment strategies aimed at minimizing clinical and radiological progression of the disease.
- The paper outlines a comprehensive workflow designed for monitoring new FLAIR lesions in MS patients using longitudinal MRI scans, targeting usability for neurologists and radiologists in France.
- Evaluation results indicate that the new workflow significantly improved lesion detection accuracy and reduced the analysis time for experts, suggesting enhanced capability in classifying MS patients' disease status.
Article Synopsis
- * To improve automation in lesion segmentation, a unique dataset has been created consisting of MRI scans from 53 MS patients, processed through a harmonized protocol across 4 different scanners, with lesions annotated by 7 experts.
- * This dataset includes both raw and preprocessed images, offering a split for training and testing, especially with data from unseen scanners, which aims to serve as a reference for evaluating and comparing various lesion segmentation methods and their performance.
Article Synopsis
- NICE lesions are rare complications that can happen after a procedure called aneurysm endovascular therapy (EVT) to treat bulging blood vessels in the brain.
- In a study of many patients, 31 people were found to have these lesions, most showing symptoms a month or so after the treatment.
- After follow-up, many patients either had no or very few lasting problems, but some still showed signs of the lesions on their brain scans even a long time later.
Background: The primary goal of the CLARYS study is to assess the protection against rebleeding when treating ruptured bifurcation aneurysms with the Woven EndoBridge (WEB) device.
Methods: The CLARYS study is a prospective, multicenter study conducted in 13 European centers. Patients with ruptured bifurcation aneurysms were consecutively included between February 2016 and September 2017.
(1) Background: Humans use reference frames to elaborate the spatial representations needed for all space-oriented behaviors such as postural control, walking, or grasping. We investigated the neural bases of two egocentric tasks: the extracorporeal subjective straight-ahead task (SSA) and the corporeal subjective longitudinal body plane task (SLB) in healthy participants using functional magnetic resonance imaging (fMRI). This work was an ancillary part of a study involving stroke patients.
View Article and Find Full Text PDFObjectives: The severity of neurocognitive impairment increases with prematurity. However, its mechanisms remain poorly understood. Our aim was firstly to identify multiparametric magnetic resonance imaging (MRI) markers that differ according to the degree of prematurity, and secondly to evaluate the impact of clinical complications on these markers.
View Article and Find Full Text PDFBackground: Major depressive disorder (MDD) is characterized by impaired cortical-subcortical functional connectivity. Apathy adds to functional impairment, but its cerebral basis in MDD remains unknown. Our objective was to describe impairments in functional connectivity during emotional processing in MDD (with varying levels of congruency and attention), and to determine their correlation with apathy.
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- The study evaluates the effectiveness of fluid and white matter suppression (FLAWS) imaging for high-resolution T mapping with minimal bias at a 7T magnetic field strength.
- FLAWS sequence was optimized for 0.8-mm isotropic resolution and compared against the MP2RAGE sequence in terms of accuracy, precision, and contrast-to-noise ratio (CNR) through tests on six healthy volunteers.
- Results indicated that FLAWS provided higher CNR and closely matched T values when compared to MP2RAGE, demonstrating its potential as an effective tool for high-resolution imaging in brain studies.
Article Synopsis
- During the COVID-19 pandemic, the World Health Organization's social distancing guidelines led to fewer endovascular therapy (EVT) treatments for patients with acute ischemic stroke caused by large vessel occlusion.
- A study involving data from 17 stroke centers across multiple countries found that the average number of EVT procedures significantly dropped by 32% after confinement measures were implemented.
- Additionally, the average time from stroke onset to treatment increased by approximately 54 minutes, indicating delays in care during the pandemic.
Objective: To describe neuroimaging findings and to report the epidemiologic and clinical characteristics of patients with coronavirus disease 2019 (COVID-19) with neurologic manifestations.
Methods: In this retrospective multicenter study (11 hospitals), we included 64 patients with confirmed COVID-19 with neurologic manifestations who underwent a brain MRI.
Results: The cohort included 43 men (67%) and 21 women (33%); their median age was 66 (range 20-92) years.
Article Synopsis
- Background: The study examines brain MRI abnormalities in patients with severe COVID-19 (SARS-CoV-2) and identifies potential neurological issues related to the virus.
- Methods: Researchers analyzed data from 37 hospitalized patients who had neurological symptoms and abnormal brain MRIs between March and April 2020, excluding cases with ischemic strokes or unrelated chronic lesions.
- Results: The patient cohort, primarily older men, exhibited various neurological symptoms, with MRI findings showing significant abnormalities in brain regions including the medial temporal lobe and evidence of microhemorrhages, suggesting COVID-19's impact on brain structure.