Publications by authors named "Jean C Gris"
Article Synopsis
- The novel coronavirus is a top concern for the international medical community due to its complex effects on the body and varying research findings.
- Vascular complications have emerged as the most severe consequence of COVID-19, significantly contributing to patient mortality.
- Certain groups, particularly pregnant women and those with specific medical histories, are at heightened risk, making the use of low-molecular-weight heparins important for prevention and treatment.
Objective: To evaluate whether urinary levels of placental growth factor (PlGF) during pregnancy are associated with the subsequent development of composite adverse outcomes (preeclampsia, fetal growth restriction, placental abruption, perinatal death, maternal death) occurring at less than 34 weeks of gestation.
Methods: This is a preplanned ancillary study of the Heparin-Preeclampsia trial, a randomized trial in pregnant women with a history of severe early-onset preeclampsia (less than 34 weeks of gestation). In the parent study, all women were treated with aspirin and then randomized to receive either low-molecular-weight (LMW) heparin or aspirin alone.
Article Synopsis
- This study investigates whether using low-molecular-weight heparin (LMW heparin) alongside aspirin during pregnancy can change the levels of specific angiogenic factors related to preeclampsia and fetal growth issues.
- Data was collected from 185 pregnant women with a history of severe early-onset preeclampsia, analyzing their serum levels of three angiogenic factors across various stages of pregnancy.
- The results showed that there were no significant differences in the angiogenic profiles between those receiving LMW heparin and those on aspirin alone, suggesting that LMW heparin may not provide the expected clinical benefits.
Context: Blood transfusion has increased significantly during the last decade and blood wastage reduction is a medical and economic challenge in hospital practice and for institutional quality, particularly in the ICU and operating theatre.
Objective: To evaluate the impact of multiple strategies in one hospital to reduce red blood cell wastage.
Design: Multicentre, prospective, comparative, observational study.
Introduction: Management of pregnant women at risk for venous thromboembolism (VTE) remains complex. Guidelines do not definitively fix optimal strategies due to limited trial data. Our objective was to build an easy-to-use tool allowing individualised, risk-adapted prophylaxis.
View Article and Find Full Text PDFThe association between the R353Q and -323P0/10 (10-bp insertion in the promoter region at position -323) factor VII mutations and plasma factor VII levels was investigated in a group of 214 healthy Tunisians. The frequency for the Q allele was 0.253 and that for the 10-bp allele was 0.
View Article and Find Full Text PDFAcute DIC is a rare, but life-threatening complication of metastatic prostate cancer. The authors discuss the treatment modalities in the light of three cases and a review of the recent literature. The key to treatment of DIC is treatment anti of the tumour.
View Article and Find Full Text PDFIn order to understand the role of the insulin receptor substrate-2 (IRS2) gene (chromosome region: 13q34) in obesity, a complex disorder associated with insulin resistance and glucose intolerance, we determined single nucleotide polymorphims (SNPs) and complex haplotypes in women with morbid obesity and a body mass index (BMI) of 41+/-0.8 kg/m2 ( n=99) compared with controls having a BMI of 23.8+/-0.
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