The effect of a pressure ventilatory support on quadriceps endurance is maintained after exercise training in severe COPD patients. A longitudinal randomized, cross over study.

In severe chronic obstructive pulmonary disease (COPD) patients, the application of an inspiratory pressure support (IPS) during exercise increases exercise tolerance and the benefit of exercise training during pulmonary rehabilitation (PR). Moreover, it improves quadriceps endurance after a session of cycling exercise suggesting a reduced muscle fatigue. We looked for the persistence of this effect after PR and sought an association between the improved quadriceps endurance with IPS and the training load during PR.

Predictors of high-degree conduction disturbances and pacemaker implantation after transcatheter aortic valve replacement: Prognostic role of the electrophysiological study.

Background: Predictors of high-degree atrioventricular block (HAVB) after transcatheter aortic valve replacement (TAVR) are recognized, but the electrophysiological study's (EPS) role is still a subject to debate. The objective of our study was to determine factors associated with PPM implantation including the potential role of EPS before and/or after TAVR.

Methods And Results: Seventy four consecutive patients (pts) were included and 21 pts (28.

A 7-year follow-up study of obstructive sleep apnoea in healthy elderly: The PROOF cohort study.

Background And Objective: Clinical and epidemiological cohort studies have shown that obstructive sleep apnoea (OSA) is a common but largely undiagnosed disorder in senior subjects, where progressive deterioration of the pathology would be expected as a consequence of the ageing processes. Our study examines the longitudinal progression of OSA over a 7-year period in a community-based sample of healthy subjects.

Methods: The sample consisted of 284 volunteers, aged >65 years (52% women, 48% men) accepting clinical and instrumental follow-up at 7 years.

Is there an association between altered baroreceptor sensitivity and obstructive sleep apnoea in the healthy elderly?

Obstructive sleep apnoea (OSA) is associated with a rise in cardiovascular risk in which increased sympathetic activity and depressed baroreceptor reflex sensitivity (BRS) have been proposed. We examined this association in a sample of healthy elderly subjects with unrecognised OSA. 801 healthy elderly (aged ≥65 years) subjects undergoing clinical, respiratory polygraphy and vascular assessment were examined.

Diurnal and nocturnal cardiovascular variability and heart rate arousal response in idiopathic hypersomnia.

Objectives: Autonomic nervous system dysfunction has been described in narcolepsy with cataplexy affecting sympathetic functions. In this study we analyzed whether altered diurnal and nocturnal cardiovascular control is present in idiopathic hypersomnia (IH).

Methods: Fourteen drug-free patients aged 26.

Skin tumours and skin aging in 209 French elderly people: the PROOF study.

Few studies have evaluated the prevalence of skin tumours in the geriatric population and none have analysed different skin aging parameters for whole-body skin in this population. To evaluate the prevalence of skin tumours and global skin aging in a French cohort of elderly people. In total, 209 subjects, 105 women and 104 men (mean age: 77.

Risk factors of osteoporosis in healthy elderly with unrecognized obstructive sleep apnea: role of physical activity.

Objective: Several studies suggest a relationship between bone mineral density (BMD) anthropometric and metabolic variables, and obstructive sleep apnea (OSA); all of these factors have an effect on osteoporosis (OS) risk. This cross-sectional study explores these associations in a large sample of older subjects with and without OSA.

Methods: Volunteers were recruited from the PROgnostic indicator OF cardiovascular and cerebrovascular events survey.

Mood disorders in healthy elderly with obstructive sleep apnea: a gender effect.

Objective: Previous studies have suggested an association between obstructive sleep apnea (OSA) and anxiety and depression, but it remains unclear as to whether this is due to OSA or other factors. The aim of this study was to evaluate this association in a large sample of healthy elderly with unrecognized OSA.

Methods: 825 healthy elderly (aged ≥65 years) undergoing clinical, respiratory home polygraphic study and completion of questionnaires related to depression, anxiety and sleepiness were examined.

Identification and comparison of the predictors of maximal inspiratory force and handgrip in a healthy elderly population. The proof study.

Background: A severe weakness of peripheral muscles occurs in half of the persons aged 80 years or older. The common factors between muscle depletion and reduced respiratory strength have not yet been established.

Objective: In the subjects of the Proof cohort, we aimed to identify, among body composition, pulmonary function and energy expenditure parameters, the predictors of maximal inspiratory pressure (MIP) as an index of respiratory muscle strength and handgrip (HG) as an index of peripheral muscle strength.

Prevalence and determinants of subjective sleepiness in healthy elderly with unrecognized obstructive sleep apnea.

Objective: Obstructive sleep apnea (OSA) is associated with behavioral consequences such as excessive daytime sleepiness (EDS). The aim of this study was to establish the presence of sleepiness in elderly with unrecognized OSA and the factors explaining its occurrence.

Methodology: A total of 825 healthy elderly (aged ≥65 years) undergoing clinical, respiratory polygraphy, and heart-rate variability analysis were studied.

Association of body fat composition and obstructive sleep apnea in the elderly: A longitudinal study.

Objective: Obesity and aging are considered risk factors for developing sleep apnea syndrome (OSA). The aim of this study was to determine the association between body fat composition and OSA in healthy elderly subjects examined in a 7-year longitudinal study.

Methods: A total of 209 elderly with unrecognized OSA aged 68.

Echocardiographic Findings in Healthy Elderly People with Unrecognized Sleep Disordered Breathing.

Objective: Sleep disordered breathing (SDB) is associated with cardiovascular disease such as hypertension and left ventricular hypertrophy in middle-aged patients; however, this association is not well described in the elderly. The aim of this study was to evaluate the impact of unrecognized SDB on cardiac function and remodeling in a population-based sample of healthy elderly without cardiac disease.

Methodology: A total of 405 healthy elderly (age ≥ 65 years) were examined by echocardiography and respiratory polygraphy.

Protective Effect of Long-Term CPAP Therapy on Cognitive Performance in Elderly Patients with Severe OSA: The PROOF Study.

Objective: Obstructive sleep apnea syndrome (OSA) leads to a deterioration in cognitive functions, with regard to memory and executive functions. However, few studies have investigated the impact of treatment on these cognitive functions in elderly subjects.

Methods: The study was conducted in a large cohort of subjects aged 65 years or older (the PROOF cohort).

Eight-year parallel change in baroreflex sensitivity and memory function in a sample of healthy older adults.

Objectives: To examine whether changes in the cardiac autonomic nervous system (ANS) over time, as expressed by baroreflex sensitivity (BRS), were associated with long-term changes in cognitive performance in elderly individuals without dementia.

Design: Community-based 8-year longitudinal study.

Setting: Clinical settings.

Modeling of performance and ANS activity for predicting future responses to training.

Purpose: Our aim was to assess whether we can predict satisfactorily performance in swimming and high frequency power (HF power) of heart rate variability from the responses to previous training. We have tested predictions using the model of Banister and the variable dose-response model.

Methods: Data came from ten swimmers followed during 30 weeks of training with performance and HF power measured each week.

Sleep breathing disorders and cognitive function in the elderly: an 8-year follow-up study. the proof-synapse cohort.

Study Objectives: Sleep breathing disorder (SBD) may be an important factor in age-related cognitive decline. In a cohort of healthy elderly subjects, we performed an 8-y longitudinal study to assess whether changes in cognitive function occur in untreated elderly patients with SBD and without dementia and the factors implicated in these changes.

Design: A population-based longitudinal study.

Association of self-reported sleep and hypertension in non-insomniac elderly subjects.

Objectives: Sleep duration and sleep quality play important roles in the development of hypertension (HT) in middle-aged subjects, with controversial data in elderly. In this study, we investigated the link between HT and self-reported sleep in non-insomniac elderly subjects.

Methods: We examined 500 participants without insomnia complaints aged 72 ± 1 years.

Prediction of pulmonary restriction from forced vital capacity in elderly is similar using GLI and ERS equations.

Introduction: The prevalence of pulmonary restriction increases in the elderly and detection could be challenging due to the difficulty in measuring lung volumes in older patients. The recently published Global Lung Function Initiative (GLI) equations were found to predict better restriction in middle-aged patients compared to ERS'93 norms. However, the ability of the GLI equations to detect pulmonary restriction in older patients has not been investigated.

Baroreflex sensitivity, vascular risk factors, and cognitive function in a healthy elderly population: the PROOF cohort.

Objectives: To assess the role of the cardiac autonomic nervous system (ANS), as measured according to spontaneous cardiac baroreflex sensitivity (BRS), in the type and degree of cognitive performance in healthy young-elderly individuals, taking into account the presence of other vascular risk factors.

Design: Community-based cross-sectional study.

Setting: In-home and clinical settings.

Sleep perception in non-insomniac healthy elderly: a 3-year longitudinal study.

Objectives: Older adults complain of sleep disturbances more often than younger adults do. It is not clear whether the age-related rise in sleep problems is related to aging itself or to health-related quality of life. The aim of this study was to explore the presence of self-reported sleep problems in healthy elderly individuals and to evaluate whether changes occurred over a 3-year follow-up.

A model for the training effects in swimming demonstrates a strong relationship between parasympathetic activity, performance and index of fatigue.

Competitive swimming as a physical activity results in changes to the activity level of the autonomic nervous system (ANS). However, the precise relationship between ANS activity, fatigue and sports performance remains contentious. To address this problem and build a model to support a consistent relationship, data were gathered from national and regional swimmers during two 30 consecutive-week training periods.