Publications by authors named "Jean Bernard Delobel"
Article Synopsis
- VIPomas are rare tumors that cause life-threatening hormonal issues by secreting vasoactive intestinal peptide (VIP), and plasma VIP can be measured to confirm diagnosis, although interference in tests can occur.
- Researchers developed three methods to detect potential interference in VIP radioimmunoassay (RIA) tests and studied both patients suspected of false positive VIP results and those with confirmed VIPomas.
- Their results showed that all false positive patients had interference in the tests, whereas no such issues were found in confirmed VIPoma patients, indicating the importance of using their developed techniques when test results don't match clinical symptoms.
Background: To identify predictors of acute and late rectal toxicity following prostate cancer radiotherapy (RT), while integrating the potential impact of RT technique, dose escalation, and moderate hypofractionation, thus enabling us to generate a nomogram for individual prediction.
Methods: In total, 972 patients underwent RT for localized prostate cancer, to a total dose of 70 Gy or 80 Gy, using two different fractionations (2 Gy or 2.5 Gy/day), by means of several RT techniques (3D conformal RT [3DCRT], intensity-modulated RT [IMRT], or image-guided RT [IGRT]).
Background: Efficacy of azathioprine (AZA) in refractory ulcerative proctitis (UP) is unknown.
Methods: All patients treated with AZA for refractory UP in three referral centers between 2002 and 2012 were included. "Treatment success" in the long-term was defined as the absence of colectomy during follow-up, no need for anti-TNF during follow-up, no ongoing systemic steroids use, no adverse event leading to AZA withdrawal, and clinically quiescent disease at last follow-up.
As our understanding of iron metabolism improves through the more accurate description of iron metabolism actors, new causes of iron overload are identified. We, here, report 16 cases of hereditary hypotransferrinemia related to 4 previously undescribed TF (transferrin) mutations (p.Val221Gly, p.
View Article and Find Full Text PDFExternal beam radiotherapy is commonly prescribed for prostate cancer. Although new radiation techniques allow high doses to be delivered to the target, the surrounding healthy organs (rectum and bladder) may suffer from irradiation, which might produce undesirable side-effects. Hence, the understanding of the complex toxicity dose-volume effect relationships is crucial to adapt the treatment, thereby decreasing the risk of toxicity.
View Article and Find Full Text PDFObjective: To analyze late urinary toxicity after prostate cancer radiotherapy (RT): symptom description and identification of patient characteristics or treatment parameters allowing for the generation of nomograms.
Methods: Nine hundred and sixty-five patients underwent RT in seventeen French centers for localized prostate cancer. Median total dose was 70 Gy (range, 65-80 Gy), using different fractionations (2 or 2.