LAMMER Kinase Modulates Cell Cycle by Phosphorylating the MBF Repressor, Yox1, in .

Lkh1, a LAMMER kinase homolog in the fission yeast , acts as a negative regulator of filamentous growth and flocculation. It is also involved in the response to oxidative stress. The deletion mutant displays slower cell growth, shorter cell size, and abnormal DNA content compared to the wild type.

Novel method for quantitative determination of amyloid fibrils of alpha-synuclein and amyloid beta/A4 protein by using resveratrol.

Amyloidosis producing insoluble fibrillar protein aggregates is the common pathological feature of various neurodegenerative disorders such as Parkinson's and Alzheimer's diseases in which alpha-synuclein and amyloid beta/A4 protein (Abeta) participate to form Lewy bodies and senile plaques, respectively. To develop a novel analytical tool for amyloidosis, resveratrol, the major phenolic constituent of red wine and isolatable from grapevines, was employed to monitor the amyloids of alpha-synuclein and Abeta. Specific interaction to the amyloids enhanced the intrinsic fluorescence of resveratrol at 395 nm with an advent of new shoulder peak at 440 nm following an excitation at 320 nm.