Publications by authors named "Je-Ho Mun"
Clinical and dermoscopic features of onychomatricoma in Korean patients.
Australas J Dermatol
August 2024
Article Synopsis
- Nummular eczema, a chronic skin condition marked by coin-shaped lesions, has unclear underlying mechanisms despite being recognized since 1857.
- A study analyzing skin samples from affected and healthy individuals revealed that the desquamation process, which is essential for skin renewal, is impaired in nummular eczema due to disorganization and increased expression of certain skin proteins.
- The research also indicated that higher levels of an inhibitor (Kazal-type-related inhibitor-1) in affected skin might prevent the normal breakdown of structures that facilitate skin shedding, contributing to delayed desquamation and symptom persistence.
Background: Studies on the interaction between tumour-infiltrating immune cells (TIICs) and tumour cells in melanoma arising from congenital melanocytic nevus (CMN) are lacking.
Objective: The aim of this study was to determine the intratumoral immune landscape of TIICs and tumour cells during invasion and metastasis.
Methods: Tissue specimens were obtained from patients with melanoma originating from CMN.
Article Synopsis
- - Primary cutaneous malignancies are a prevalent type of cancer globally, with a substantial analysis conducted on the Korean population using data from the Nationwide Cancer Registry between 1999 and 2019, revealing a 7-fold increase in diagnosed cases.
- - Significant increases were observed in age-standardized incidence rates for various skin cancers, with basal cell carcinoma rising 3.4-fold and malignant melanoma increasing 1.8-fold, showcasing diverse rates among different types of skin cancer.
- - The study indicated high 5-year relative survival rates for basal cell carcinoma (103.3%), while angiosarcoma had the lowest rate (24.7%), highlighting improvements in survival across many skin cancer types, though these improvements differed by
Article Synopsis
- The study focused on lentigo maligna (LM) and lentigo maligna melanoma (LMM), which are rare skin conditions in Asian countries, and aimed to identify histopathological features to differentiate them from benign lentigo.
- Researchers analyzed 21 patients diagnosed with LM/LMM from 2011-2022 to assess their histopathologic characteristics based on 16 criteria, comparing them with benign cases.
- Significant differences were found between LM/LMM and benign lentigo in several features, such as asymmetry, cytologic atypia, and invasion patterns, highlighting diagnostic challenges in histopathological assessments.
Rosai-Dorfman disease (RDD) is a rare non-Langerhans cell histiocytosis characterized by an accumulation of activated histiocytes within the affected tissues. It is a heterogeneous disease that includes the classical (nodal) and extra-nodal variants. The cutaneous form of the disease without the characteristic lymphadenopathy is rare and is often misdiagnosed as other dermatologic diseases.
View Article and Find Full Text PDFPeutz-Jeghers syndrome (PJS; MIM 175200) is an autosomal dominant multiple-organ cancer syndrome. It is characterized by brown macules distributed in the perioral skin, oral mucosa, hands and feet, and hamartomatous gastrointestinal polyps that can eventually lead to intestinal obstruction, abdominal pain, bleeding, and anemia. Patients with PJS are at a higher risk of ovarian, testicular, breast, lung, and pancreatic cancers.
View Article and Find Full Text PDFSuccessful Management of Periungual Acral Lentiginous Melanoma Using Secondary Intention Healing.
Dermatol Pract Concept
October 2023
Article Synopsis
- Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer that has mostly been studied in Caucasians, leaving a knowledge gap about its characteristics and prognosis in Asian populations, particularly in South Korea.
- This research, a nationwide study conducted across 12 centers, evaluated 161 patients with MCC, revealing a higher incidence in females and highlighting that the disease stage at diagnosis significantly influences overall survival rates.
- The findings indicate that MCC exhibits unique clinicopathological features in South Korea, emphasizing the importance of understanding geographical variations in cancer epidemiology.
Keloids are skin tumours caused by aberrant growth of dermal fibroblasts. Cellular senescence contributes to aging and various pathological conditions, including cancer, atherosclerosis, and fibrotic diseases. However, the effects of cellular senescence and senolytic drugs on keloids remain largely unknown.
View Article and Find Full Text PDFReflectance Confocal Microscopy in the Diagnosis of Onychomycosis: A Systematic Review.
J Fungi (Basel)
December 2022
Accurately diagnosing onychomycosis is vital, as therapy is time-consuming and accompanied by multiple adverse effects. Reflectance confocal microscopy (RCM), in contrast to traditional mycological testing, is a noninvasive, point-of-care tool that can rapidly identify fungal lesions. This systematic review aims to understand the utility of RCM in evaluating onychomycosis and follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
View Article and Find Full Text PDFDiagnostic accuracy of dermoscopy for onychomycosis: A systematic review.
Front Med (Lausanne)
October 2022
Background: Dermoscopy is a non-invasive adjuvant diagnostic tool that allows clinicians to visualize microscopic features of cutaneous disorders. Recent studies have demonstrated that dermoscopy can be used to diagnose onychomycosis. We performed this systematic review to identify the characteristic dermoscopic features of onychomycosis and understand their diagnostic utility.
View Article and Find Full Text PDFBackground: Large studies on the clinical features and natural course of pediatric longitudinal melanonychia (LM) are lacking.
Objective: To investigate the clinical features and natural course of pediatric LM.
Methods: Retrospective cohort analysis of pediatric patients (age ≤ 18 years) with LM.
Background: Congenital nail matrix nevi (NMN) are difficult to diagnose because they feature clinical characteristics suggestive of adult subungual melanoma. Nail matrix biopsy is difficult to perform, especially in children.
Objective: To describe the initial clinical and dermatoscopic features of NMN appearing at birth (congenital) or after birth but before the age of 5 years (congenital-type).
Background: Fungal dermatological diseases are significant public health issues. Dermoscopy is a useful bedside assessment tool that helps clinicians diagnose various skin neoplasms and general dermatological diseases.
Aim: This brief review aims to update clinicians on the dermoscopic features of cutaneous fungal infections such as tinea capitis, tinea corporis, tinea incognito, onychomycosis, and pityrosporum folliculitis.