Successful New Dental Implant Installation in a Healed Site of Medication-Related Osteonecrosis of the Jaw: A Case Report.

The purpose of this case report was to present a rare clinical case of successful new dental implant installation in the site of previously healed medication-related osteonecrosis of the jaw (MRONJ). An 80-year-old female patient with history of oral bisphosphonate (BP) therapy presented with pain and swelling of gingiva in the right posterior mandible. One of the 3 implants placed 15 years ago in the right mandibular posterior area was removed 6 months before the visit to our hospital, which led to worsening of the symptoms.

A new rationale for preservation of the mandibular third molar in orthognathic patients with missing molars.

Controversies exist regarding the need for prophylactic extraction of mandibular third molars in patients who plan to undergo orthognathic surgery. An 18-year-old male patient was diagnosed with mandibular prognathism and maxillary retrognathism with mild facial asymmetry. He had a severely damaged mandibular first molar and a horizontally impacted third molar.

Total Intravenous Anesthesia in a Malignant Hyperthermia-Susceptible Patient with Klinefelter Syndrome Undergoing Orthognathic Surgery.

A patient with Klinefelter syndrome and skeletal Class III malocclusion experienced a malignant hyperthermia-like reaction while undergoing orthognathic surgery. The patient fully recovered after prompt diagnosis and management, and surgery was reattempted under total intravenous anesthesia. The patient was discharged without any anesthetic complications and was satisfied with the surgical results.

NELL-1 Increased the Osteogenic Differentiation and mRNA Expression of Spheroids Composed of Stem Cells.

NELL-1 is a competent growth factor and it reported to target cells committed to the osteochondral lineage. The secreted, osteoinductive glycoproteins are reported to rheostatically control skeletal ossification. This study was performed to determine the effects of NELL-1 on spheroid morphology and cell viability and the promotion of osteogenic differentiation of stem cell spheroids.

Preemptive intravenous iron therapy versus autologous whole blood therapy for early postoperative hemoglobin level in patients undergoing bimaxillary orthognathic surgery: a prospective randomized noninferiority trial.

Background: Previous studies have reported the efficacy and safety of intravenous (IV) iron therapy during the perioperative period as an alternative and adjunct to allogeneic blood transfusion. Preemptive IV iron therapy provides noninferior hemoglobin levels on postoperative day (POD) 1 compared to autologous whole blood therapy (AWBT) in healthy patients who had undergone bimaxillary orthognathic surgery.

Methods: This was a prospective, patient-randomized, noninferiority trial.

Methylsulfonylmethane Induces G Arrest and Mitochondrial Apoptosis in YD-38 Gingival Cancer Cells.

Gingival squamous cell carcinoma is a rare form of cancer that accounts for less than 10% of all head and neck cancers. Targeted therapies with natural compounds are of interest because they possess high efficacy with fewer side-effects. Methylsulfonylmethane (MSM) is an organic sulfur-containing compound with anticancer activities.

Analgesic effects of nefopam in patients undergoing bimaxillary osteotomy: A double-blind, randomized, placebo-controlled study.

Purpose: Many studies have examined the postoperative analgesic effects of nefopam in various settings. However, although nefopam is expected to be useful in bimaxillary osteotomy, no published data are available.

Material And Methods: We divided 42 patients into nefopam [n = 21, nefopam 20 mg intravenous (i.

Stability After Bilateral Sagittal Split Osteotomy With Rigid Internal Fixation in Surgery-First Approach.

Purpose: The purpose of this study was to evaluate the stability of bilateral sagittal split ramus osteotomy (BSSO) setback with rigid internal fixation in a surgery-first approach (SFA) for patients with skeletal Class III malocclusion.

Patients And Methods: Twenty-seven consecutive patients with skeletal Class III malocclusion treated with BSSO with the SFA were included in the study. Lateral cephalograms were taken and traced before surgery and 1 and 6 months after surgery.

Vertical eruption patterns of impacted mandibular third molars after the mesialization of second molars using miniscrews.

Objective: To investigate (1) whether vertical eruption of impacted third molars improves after mesialization of second molars and (2) what factors affect the vertical eruption of impacted third molars when space caused by missing molars is successfully closed by mesialization of the second molar using miniscrews.

Materials And Methods: The treatment group (Group 1) included 52 patients who had (1) missing mandibular first molars (ML-6) or missing deciduous mandibular second molars (ML-E), (2) initially impacted mandibular third molars, and (3) successful space closure of the edentulous area with orthodontics. Panoramic radiographs at start of treatment (T1) and at time of space closure (T2) were collected.

Tannic acid inhibits the Jak2/STAT3 pathway and induces G1/S arrest and mitochondrial apoptosis in YD-38 gingival cancer cells.

Tannic acid (TA), is a potent anti-oxidant, showing anti-proliferative effects on numerous cancers. The ability of TA to induce proliferation inhibition on the rare tumor, gingival squamous cell carcinoma (GSCC), comprising <10% of all head and neck squamous cell carcinomas was studied in the YD-38 cell line. The main goal was to modulate the Jak2/STAT3 pathway using TA and to induce cell cycle arrest and apoptosis in GSCC.

Bone formation on biomimetic calcium phosphate-coated and zoledronate-immobilized titanium implants in osteoporotic rat tibiae.

Purpose: Coating prostheses with calcium phosphate (CaP) can boost ossification and provide an appropriate vehicle for drug delivery. In this study, CaP coating was performed using a biomimetic method, and zoledronate (ZOL) was incorporated to promote peri-implant bone formation in an osteoporotic environment.

Materials And Methods: Twenty female 8-week-old rats were ovariectomized to induce osteoporosis.

Osteogenic potential of adult stem cells from human maxillary sinus membrane by Simvastatin in vitro: preliminary report.

Objectives: The objective of this study is to determine the adequate concentration and to evaluate the osteogenic potential of simvastatin in human maxillary sinus membrane-derived stem cells (hSMSC).

Materials And Methods: Mesenchymal stem cells derived from the human maxillary sinus membrane were treated with various concentrations of simvastatin. The adequate concentration of simvastatin for osteogenic induction was determined using bone morphogenetic protein (BMP-2).

Evaluation of minimal versus conventional presurgical orthodontics in skeletal class III patients treated with two-jaw surgery.

Purpose: The purpose of this study was to compare changes in hard and soft tissues and the treatment efficacy of 2-jaw surgery combined with nonextraction treatment for skeletal Class III malocclusion in patients who received minimal presurgical orthodontics (MPO) versus those who received conventional presurgical orthodontics (CPO).

Materials And Methods: Thirty-two patients (16 in each group) with skeletal Class III malocclusion who underwent 2-jaw surgery were included in the study. Serial lateral cephalometric films were traced at 4 stages: before treatment (T0), before surgery (T1), 1 month after surgery (T2), and at debonding (T3).

Combined multisegmental surgical-orthodontic treatment of bialveolar protrusion and chin retrusion with severe facial asymmetry.

LeFort I osteotomy, anterior segmental osteotomy, bilateral sagittal split ramus osteotomy, and genioplasty are frequently used methods for correcting facial deformities. However, in patients with an abnormally shaped maxilla or mandible, more complex surgical techniques or multiple combinations must be considered for improved esthetic results. This article presents a patient with bialveolar protrusion, mandibular prognathism, chin retrusion, a long face, and severe facial asymmetry.

Assessment of asymmetry in a normal occlusion sample and asymmetric patients with three-dimensional cone beam computed tomography: a study for a transverse reference plane.

Objective: To characterize symmetrical features of patients with facial asymmetry and thus to find the most reliable horizontal reference lines easily used in three-dimensional images. The hypothesis was that there is a difference in the location of bilateral landmarks of the upper skull between the normal occlusion sample and skeletal Class III patients with asymmetry.

Materials And Methods: Group 1 (normal occlusion sample) was composed of 20 Korean adults with normal occlusion and no noticeable asymmetry.

Change in bite force and electromyographic activity of masticatory muscle in accordance with change of occlusal plane.

Purpose: The purpose of the present study was to evaluate effects of occlusal plane on masticatory function (biting force, masticatory muscle activity, biting efficiency) after bimaxillary orthognathic surgery.

Patients And Methods: The subjects of the present study consisted of a group of 55 adults who had undergone bimaxillary surgery more than 6 months earlier. Lateral cephalographs, bite force, and electromyographic measurements of the anterior temporal [EMG(t)] and masseter muscles [EMG(m)] were recorded before and after bimaxillary surgery.

Postoperative condylar position by sagittal split ramus osteotomy with and without bone graft.

Purpose: The purpose of the present study was to determine how the condylar position is affected by the bone graft in the intersegmental space created by sagittal split ramus osteotomy.

Patients And Methods: We compared the position of the condyle after sagittal split ramus osteotomy, without the bone graft (control group, n = 30) and with the bone graft (study group, n = 30) using computed tomography with a 2-mm thickness. Using 3-dimensional images and a 3-dimensional computer program, the pre- and postoperative displacement and rotation of the condyle in the axial (rotation and mediolateral movement of the condyle) and sagittal plane (anteroposterior and superoinferior movement of the condyle and rotation of the proximal segment) were measured.

Adult stem cells derived from human maxillary sinus membrane and their osteogenic differentiation.

Purpose: To investigate the method and conditions of isolation and proliferation of multipotent mesenchymal stem cells (MSCs) from human maxillary sinus membrane in vitro and to induce osteogenic differentiation directly for identification.

Materials And Methods: A human maxillary sinus membrane specimen was collected in aseptic conditions from an orthognathic surgery patient and cultured. The cells at passage three were sorted by flow cytometry and treated with osteogenic differentiation media.

Alveolar bone loss around incisors in surgical skeletal Class III patients.

Objective: To test the hypothesis that there is no difference in the vertical alveolar bone levels and alveolar bone thickness around the maxillary and mandibular central incisors in surgically treated skeletal Class III malocclusion patients.

Materials And Methods: The study sample comprised 20 Korean patients with skeletal Class III malocclusion with anterior crossbite and openbite (9 male, 11 female, mean ages 24.1).

Three-dimensional finite element analysis of stress distribution and displacement of the maxilla following surgically assisted rapid maxillary expansion.

Purpose: The aim of this study was to investigate the displacement and stress distributions during surgically assisted rapid maxillary expansion under different surgical conditions.

Materials And Methods: 3-dimensional finite element model of a maxilla with a Hyrax appliance was constructed and an expansion force of 6000 grams was applied using the expansion screw. According to the surgical procedures, 5 groups including a control group without surgery (Group I) were simulated.

Articular disc position in association with mandibular setback surgery.

Objective: The purpose of this study was to evaluate the influence of orthognathic surgery on articular disc position and temporomandibular disorder symptoms of skeletal class III patients by means of clinical and radiographic evaluation of the temporomandibular joint.

Study Design: Thirty-six patients with skeletal class III malocclusion, who were treated at Kangnam St. Mary's Hospital between January 2005 and January 2006, were evaluated by clinical examination and pre- and postoperative magnetic resonance imaging.

Evaluation of the soft and hard tissue changes after anterior segmental osteotomy on the maxilla and mandible.

Purpose: The purpose of this study was to determine the relationship between the changes of soft and hard tissues after modified anterior segmental osteotomy on the maxilla and mandible and to evaluate unintended facial changes using cephalometric and photometric analyses.

Materials And Methods: The subjects included 29 women and 1 man (22 to 50 years of age) who were diagnosed as bialveolar or bimaxillary protrusion and underwent modified anterior segmental osteotomy on the maxilla and mandible. Lateral cephalograms and lateral and frontal photographs taken preoperatively and postoperatively were analyzed.

Expression of E-cadherin, P-cadherin and N-cadherin in oral squamous cell carcinoma: correlation with the clinicopathologic features and patient outcome.

Purpose: Alteration of cadherin expression is associated with the loss of cellular differentiation, the acquisition of an invasive phenotype and a poor prognosis in many types of cancer. This study aimed to evaluate the immunoreactivity of E-, P- and N-cadherins (cad) in oral squamous cell carcinoma and to correlate their expression with clinicopathological features and clinical outcome. The interaction between the cadherins was also investigated.