Bioorganic compounds in quorum sensing disruption: strategies, Mechanisms, and future prospects.

Recent research has shed light on the complex world of bacterial communication through quorum sensing. This sophisticated intercellular signalling mechanism, driven by auto-inducers, regulates crucial bacterial community behaviours such as biofilm formation, expression of virulence factors, and resistance mechanisms. The increasing threat of antibiotic resistance, coupled with quorum sensing mediated response, necessitates alternative strategies to combat bacterial infections.

Metal-free efficient synthesis of aryl sulfonamides from -hydroxy sulfonamide and amines.

A simple and novel approach has been developed for the synthesis of sulfonamides from -hydroxy sulfonamide. Notably, the iodine--butyl hydroperoxide (TBHP) system efficiently promoted the sulfonylation reactions of -hydroxy sulfonamides and amines the oxidative cleavage of an S-N bond. A variety of aryl sulfonamides were prepared in moderate to good yields using readily available starting materials and the biomass-derived 2-MeTHF solvent.