Publications by authors named "Jayron J Habibe"
Article Synopsis
- Type 2 diabetes mellitus (T2D) often occurs with dyslipidemia, and a study investigated how the FHL2 protein might relate to these conditions in a diverse group of 10,056 participants from the HELIUS study in Amsterdam.
- The research found seven genetic variants of FHL2 related to unhealthy lipid profiles, like high triglycerides and LDL-C, but not directly linked to T2D or blood glucose levels overall.
- When looking specifically at the Ghanaian subgroup, two genetic variants showed significant associations with lipid levels, highlighting the importance of ethnic diversity in metabolic disease studies.
The LIM-domain-only protein FHL2 is a modulator of signal transduction and has been shown to direct the differentiation of mesenchymal stem cells towards osteoblast and myocyte phenotypes. We hypothesized that FHL2 may simultaneously interfere with the induction of the adipocyte lineage. Therefore, we investigated the role of FHL2 in adipocyte differentiation.
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- The study examines the role of FHL2, a protein that increases with age, in glucose metabolism and insulin secretion, particularly in the context of rising rates of type 2 diabetes as the population ages.
- Researchers analyzed data from human pancreatic islets, performed tests on FHL2-deficient mice, and manipulated FHL2 levels in MIN6 cells to explore its function.
- Findings showed that FHL2-deficient mice could clear glucose more effectively and secrete more insulin than normal mice, suggesting that high levels of FHL2 may negatively impact insulin secretion pathways and glucose metabolism.
Susceptibility to complex pathological conditions such as obesity, type 2 diabetes and cardiovascular disease is highly variable among individuals and arises from specific changes in gene expression in combination with external factors. The regulation of gene expression is determined by genetic variation (SNPs) and epigenetic marks that are influenced by environmental factors. Aging is a major risk factor for many multifactorial diseases and is increasingly associated with changes in DNA methylation, leading to differences in gene expression.
View Article and Find Full Text PDFObjective: Four-and-a-Half-LIM-domain-protein 2 (FHL2) modulates multiple signal transduction pathways but has not been implicated in obesity or energy metabolism. In humans, methylation and expression of the FHL2 gene increases with age, and high FHL2 expression is associated with increased body weight in humans and mice. This led us to hypothesize that FHL2 is a determinant of diet-induced obesity.
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