Publications by authors named "Jaynelle Gao"
Objective: There has been limited research on the influence of race and ethnicity on treatment decision-making for chronic rhinosinusitis (CRS). This prospective study aims to investigate potential factors linked to treatment modality choice among patients with medically refractory CRS, distinguishing between Chinese American and non-Chinese American patients.
Methods: CRS patients with persistent symptoms despite prior medical treatment were prospectively enrolled.
Article Synopsis
- Epidemiologic studies suggest a significant link between autoimmune conditions and psychiatric disorders like obsessive-compulsive disorder, indicating potential new treatment options by understanding inflammation's role in these mental health issues.
- The study focused on pediatric acute-onset neuropsychiatric syndrome (PANS), investigating immune activation and the risk of autoimmune diseases such as arthritis during symptom flare-ups in 193 children at the Stanford Immune Behavioral Health Clinic.
- Researchers reviewed medical records to analyze immune markers and signs of autoimmune diseases, ultimately estimating the risk of developing arthritis and characterizing different arthritis types among the participants.
Importance: Studies of brain imaging and movements during REM sleep indicate basal ganglia involvement in pediatric acute-onset neuropsychiatric syndrome (PANS). Characterizing neurological findings commonly present in patients with PANS could improve diagnostic accuracy.
Objective: To determine the prevalence of neurological soft signs which may reflect basal ganglia dysfunction (NSS-BG) in youth presenting with PANS and whether clinical characteristics of PANS correlate with NSS-BG.
Sex and Aggression Characteristics in a Cohort of Patients with Pediatric Acute-Onset Neuropsychiatric Syndrome.
J Child Adolesc Psychopharmacol
October 2022
Article Synopsis
- This study investigates the differences by sex in patients with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS), examining clinical characteristics, treatment, and psychosocial factors among 205 patients, with 87 females and 118 males.
- Results showed that males had higher aggression scores compared to females, as measured by the Modified Overt Aggression Scale (MOAS), and generally received immunotherapy treatment sooner despite no significant differences in age of onset or overall impairment levels between sexes.
- While males exhibited more aggressive behavior, both sexes experienced similar overall functioning impairments, suggesting that sex may influence treatment decisions without affecting overall disease severity.
Treatment decision-making among Asian Americans with chronic rhinosinusitis.
Int Forum Allergy Rhinol
December 2022
Objectives: Pediatric acute-onset neuropsychiatric syndrome (PANS) is characterized by an abrupt-onset of severe psychiatric symptoms including OCD, anxiety, cognitive difficulties, and sleep issues which is thought to be a post-infection brain inflammatory disorder. We observed postural orthostatic tachycardia syndrome (POTS) which resolved with immunomodulation in a patient with Pediatric acute-onset neuropsychiatric syndrome (PANS). Here, we aim to present a case of POTS and to examine the prevalence of (POTS) in our PANS cohort, and compare the clinical characteristics of patients with and without POTS.
View Article and Find Full Text PDFImportance: Epidemiological studies indicate a link between obsessive-compulsive disorder and infections, particularly streptococcal pharyngitis. Pediatric acute-onset neuropsychiatric syndrome (PANS) manifests suddenly with obsessions, compulsions, and other behavioral disturbances, often after an infectious trigger. The current working model suggests a unifying inflammatory process involving the central nervous system, particularly the basal ganglia.
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