Monitoring of cyclosporine 2-hour post-dose levels in heart transplantation: improvement in clinical outcomes.

Background: Cyclosporine 2-hour post-dose (C2) monitoring is predictive of outcomes in solid-organ transplants. The purpose of this study was to determine C2 levels at various time points after heart transplantation and determine whether trough (C0) or C2 better predicts clinical outcomes.

Methods: This was a 2-phase prospective study with paired determinations of cyclosporine levels at C0 and C2 in 58 heart transplant patients (46 men; mean age, 56 years).

Clinical benefits of neoral C2 monitoring in the long-term management of renal transplant recipients.

Background: Cyclosporine monitoring using the 2-hr postdose sample, C2, has been shown to have advantages in monitoring de novo renal transplant recipients. The purpose of this study was to assess cyclosporine exposure, using C2, in stable renal transplant patients previously monitored by C0 to determine the effect of dose reduction on patients with C2 more than 10% above target and the course of those with C2 at and more than 10% below target, whose dose was not modified.

Methods: One hundred and seventy-five patients, three or more months after transplantation, had C2 assessed.