Publications by authors named "Jaymie R Sawyer"

Article Synopsis
  • - The text discusses a novel molecular electronics chip that utilizes single molecules as general-purpose sensors, allowing for ultra-miniaturized electronic circuits.
  • - The device features a semiconductor chip with an array of synthetic molecular wires connected to nanoelectrodes, enabling real-time monitoring of molecular interactions at high speeds (1,000 frames per second).
  • - It demonstrates the ability to measure single-molecule interactions, such as those involving DNA, antibodies, and enzymes, with exceptional sensitivity and without needing labels, which can enhance various applications in biosensing and diagnostics.
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As Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to spread, characterization of its antibody epitopes, emerging strains, related coronaviruses, and even the human proteome in naturally infected patients can guide the development of effective vaccines and therapies. Since traditional epitope identification tools are dependent upon pre-defined peptide sequences, they are not readily adaptable to diverse viral proteomes. The Serum Epitope Repertoire Analysis (SERA) platform leverages a high diversity random bacterial display library to identify proteome-independent epitope binding specificities which are then analyzed in the context of organisms of interest.

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Previous herpes simplex virus type 2 (HSV-2) vaccines have not prevented genital herpes. Concerns have been raised about the choice of antigen, the type of antibody induced by the vaccine, and whether antibody is present in the genital tract where infection occurs. We reported results of a trial of an HSV-2 replication-defective vaccine, HSV529, that induced serum neutralizing antibody responses in 78% of HSV-1-/HSV-2- vaccine recipients.

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Article Synopsis
  • Standard two-tier testing (STTT) for Lyme disease often misses early infections, resulting in many false-negative results each year.
  • A study introduced serum antibody repertoire analysis (SERA) using next-generation sequencing to identify specific antibody motifs for better detection of Lyme disease.
  • The SERA assay showed improved sensitivity (77% vs. 62%) and specificity (99% vs. 97%) compared to STTT in early Lyme disease, making it a more accurate testing method.
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