Synopsis of recent research by authors named "Jayhyuk Myung"
- Jayhyuk Myung's recent research primarily focuses on the development of non-thiazolidinedione (non-TZD) PPARγ agonists for the treatment of type 2 diabetes, exemplified by the identification of BR102375 and BR101549 as promising candidates with comparable efficacy to established drugs like Pioglitazone.
- Through structure-activity relationship (SAR) studies, Myung has explored novel compounds derived from anti-hypertensive drugs, which demonstrated significant glucose-lowering effects in preclinical models, although weight gain suppression was not observed as anticipated.
- In addition to diabetes research, Myung has investigated the role of autocrine motility factor (AMF) in cancer progression, showing that monoclonal antibodies targeting AMF can inhibit the growth of gastric cancer, indicating a potential therapeutic strategy in oncology.
