Publications by authors named "Jayaprakash Thulukanam"
Article Synopsis
- Cryptococcus is a dangerous fungal pathogen responsible for nearly 250,000 cases and 181,000 deaths from cryptococcal meningitis each year, particularly impacting vulnerable populations like HIV patients and organ transplant recipients.
- Treating cryptococcal infections is complicated by antifungal resistance, emphasizing the need for effective control measures and innovative treatment strategies.
- Nanoparticle-based therapies show promise as advanced antifungal solutions, highlighting the necessity for further research to combat antifungal resistance and improve treatment for cryptococcal infections.
Hyperglycemia, a key characteristic of type 2 diabetes mellitus (T2DM), highlights the need for effective management strategies. This study aims to analyze the impact of multistrain probiotic supplementation on glycemic control in T2DM patients. During a 24-week randomized controlled trial involving 130 participants, subjects were assigned to either a probiotic group or a placebo group.
View Article and Find Full Text PDFHepatitis B virus (HBV) infection remains a significant global health challenge, with chronic HBV leading to severe liver diseases, including cirrhosis and hepatocellular carcinoma. Current treatments often fail to eradicate the virus, highlighting the need for innovative therapeutic strategies. The CRISPR/Cas9 system has emerged as a dynamic tool for precise genome editing and presents a promising approach to targeting and eliminating HBV infection.
View Article and Find Full Text PDFBackground: Tuberculosis is an infectious disease responsible for a significant cause of ill health. According to the WHO global tuberculosis report 2021. 9.
View Article and Find Full Text PDFIntroduction: Pseudomonas aeruginosa (PA) possesses several virulence genes that enable them to evade the immune system and to cause injury in the host tissue. However, the number of studies that characterized the virulence genes profile in PA sepsis is limited.
Aim: The main objective of this study was to identify and characterize virulence genes in PA causing sepsis, as well as investigate the relationship between virulence genes, antimicrobial susceptibility patterns, and infection outcomes.