Publications by authors named "Jayaprakash J"

Article Synopsis
  • The study introduces MS2Lipid, a machine learning model designed to improve the prediction of lipid subclasses from mass spectrometry data, overcoming limitations in existing software that rely on manual curation.
  • The model achieves an impressive 97.4% accuracy in classifying lipid subclasses from extensive datasets, using a new descriptor called MCH for better specificity.
  • MS2Lipid's effectiveness is further demonstrated through its application in annotating lipid metabolites linked to obesity, highlighting its potential for biological and clinical lipidomics research.
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  • N6-methyladenosine (m6A) is a crucial regulator in RNA functions and is linked to cancer, particularly head and neck squamous cell carcinoma (HNSCC), which has a low survival rate.
  • Research indicates that m6A RNA methylation is elevated in HNSCC and affects various cancer-related processes like growth, cell death, and metastasis.
  • The study suggests that m6A modifications can serve as potential biomarkers for diagnosing and predicting outcomes in HNSCC and aims to provide a thorough review of m6A's role in cancer mechanisms.
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  • * Participants aged 12-19 took the IgY tablets for 15 days, and saliva samples were collected at various intervals to measure bacterial levels.
  • * Results showed that the IgY tablets significantly decreased bacterial counts, suggesting they can be a helpful addition to oral hygiene practices during orthodontic treatment.
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The study presents AgCrO/FeO/CeO ternary nanocomposite, based on FeO/CeO binary composites, which demonstrated excellent photocatalytic performance in the photodegradation of methylene blue under solar irradiation. The AgCrO/FeO/CeO nanocomposites was orthorhombic, ilmenite, and cubic-fluorite phases of AgCrO, FeO, and CeO, respectively, according to the XRD examination. A strong bond between AgCrO, FeO, and CeO within the nanocomposite was demonstrated by the SEM and TEM investigations.

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Sphingomyelin synthase (SMS) is a sphingolipid-metabolizing enzyme involved in the synthesis of sphingomyelin (SM) from ceramide (Cer). Recent studies have indicated that SMS is a key therapeutic target for metabolic diseases such as fatty liver, type 2 diabetes, atherosclerosis, and colorectal cancer. However, very few SMS inhibitors have been identified because of the limited sensitivity and selectivity of the current fluorescence-based screening assay.

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Consumption of alcohol has widespread effects on the human body. The organs that are most significantly impacted are the liver and digestive system. When alcohol is consumed, it is absorbed in the intestines and processed by the liver.

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Aim: This study was planned to evaluate and compare the cleaning efficacy of three pediatric rotary files with the standard Protaper adult file system in primary teeth using cone-beam computed tomography (CBCT).

Materials And Methods: A total of 40 extracted deciduous second molars, with palatal/mesial roots having at least two-thirds of root length and an intact furcation area, were distributed randomly among four groups, with each group containing 10 teeth. Canal preparation of group I (Pro AF Baby Gold), group II (Kedo SG Blue), group III (Prime Pedo), and group IV (Protaper) was done.

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Article Synopsis
  • - The integration of biology and computational science has transformed our understanding of biological systems and paved the way for innovative solutions to global issues like disease and environmental challenges.
  • - Genetic engineering and biomolecular simulation are key components of this evolution, offering insights into molecular processes and enabling the development of advanced therapies for genetic disorders and new pharmaceuticals.
  • - The ongoing advancements in computational biology are expected to significantly impact fields like cancer treatment and environmental restoration, showcasing its potential to revolutionize our understanding and enhancement of biological systems.
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Eukaryotes carry hundreds of ribosomal RNA (rRNA) genes as tandem arrays, which generate rRNA for protein synthesis. Humans carry ∼ 400 rRNA gene copies and their expression is epigenetically regulated. Dysregulation of rRNA synthesis and ribosome biogenesis are characteristic features of cancers.

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It is well established that exposure to ambient air pollution affects human health. A majority of literature concentrated on health effects of air pollution in high income countries. Only fewer studies analyzing health effects of air pollution in Low- and Middle-Income Countries (LMICs) are available.

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Hospitals provide direct and indirect employment benefits to medical professionals. Accidents in hospitals often lead to disastrous consequences such as fatalities, property damage and economic losses. It is, therefore, imperative to have an occupational health and safety (OHS) policy that aims to reduce work-related accidents to acceptable levels.

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India produces around 19.0 million tonnes of tomatoes annually, which is insufficient to meet the ever-increasing demand. A big gap of tomato productivity (72.

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Bacterial infection remains a great challenge in wound healing, especially in chronic wounds. Multidrug-resistant organisms are increasing in acute and chronic wound infections, which compromise the chance of therapeutics. Resistance to conventional antibiotics has created an urge to study new approach/system that can effectively control wound infection and enhance healing.

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Low cost and eco-friendly green synthesis of silver nanoparticles (AgNPs) from silver nitrate (AgNO) using Prunus japonica leaves extract as reducing agent by a simple method at room temperature. The biosynthesized nanoparticles (NPs) were characterized by UV-Vis, tunneling electron microscopy (HR-TEM), scanning electron microscopy (SEM) coupled with X-ray energy dispersive spectrophotometer (EDAX), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). In UV-Vis spectroscopy results, the λ was observed at 441 nm.

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Introduction: Dental caries is a common dental disease, which occurs during childhood and continues to be a major public health problem. The prevalence of dental caries was associated with oral hygiene practice, sugar consumption and implementation of the preventive oral health program.

Aim: The purpose of this study was to assess the prevalence of dental caries in school children aged between 6-14 years using the International Caries Detection and Assessment System (ICDAS II).

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Campylobacter fetus is a Gram-negative bacterium that has caused several cases of human and animal disease. Here, we report the draft genome sequence of C. fetus MMM01, isolated from the blood of a 60-year-old patient with type II diabetes and chronic kidney disease.

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Pure CuO and Zn-doped CuO nanoparticles were synthesized from sol-gel process by reacting copper acetate monohydrate with a urea in distilled water at 80°C. The synthesized Samples were different concentrations but same annealing temperature at 400°C. The obtained samples were characterized by means of UV-visible spectroscopy (UV-vis), X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FT-IR), Field emission scanning electron microscopy (FE-SEM) and Energy dispersive X-ray spectroscopy (EDS).

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Vasopressin is often used locally to reduce blood loss during surgery. Vasopressin has longest clinical effect, but its systemic effects may be profound and pose significant challenges for the anesthesiologist and it can also sometimes cause lethal complications. The loss of peripheral pulse along with bradycardia, non-measurable arterial blood pressure, and cardiac complications have been reported after myometrial injection of vasopressin.

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The uncapped and capped CuO nanoparticles were synthesized by sol-gel process. Ethylene diamine tetra acetic acid (EDTA) used as a capping agent to control the size and morphology of the CuO nanoparticles. Control the nanostructure and optical properties of CuO nanoparticles are deliberate by using capping agent.

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