Pharmacokinetic and pharmacodynamic studies of etodolac loaded vesicular gels on rats by transdermal delivery.

Background: The present study includes the development of liposomal and ethosomal gels for transdermal delivery to overcome the side effects associated with oral route.

Methods: The liposomes and ethosomes were prepared by 3 factorial design using film hydration and cold methods, respectively. Different concentrations of liposomal (ETO-LG) and ethosomal (ETO-EG) gels were prepared at 1%, 2 and 3% (w/v) using carbopol 940 NF.