Substance P-A neuropeptide regulator of periodontal disease pathogenesis and potential novel therapeutic entity: A narrative review.

Substance P (SP), a neuropeptide primarily released by neurons, has emerged as a key player in the intricate network of factors governing periodontal inflammation, immune responses, bone metabolism, and tissue regeneration. Due to its multifaceted role, it may be explored for its potential participation in periodontal therapeutic strategies. The databases, PubMed/MEDLINE, and SCOPUS were searched for all published articles on SP, its role in inflammation, and periodontal disease.

FPGA-based low-light image enhancement using Retinex algorithm and coarse-grained reconfigurable architecture.

Advancements in digital imaging and video processing are often challenged by low-light environments, leading to degraded visual quality. This affects critical sectors such as medical imaging, aerospace, and underwater exploration, where uneven lighting can compromise safety and clarity. To enhance image quality in low-light conditions using a computationally efficient system.

Mysterious alarming mucormycosis: Anesthetic challenges in a series of four cases.

The sudden epidemic of mucormycosis amid COVID-19 pandemic has significantly challenged our understanding of the disease while affecting the whole medical and surgical management. Overzealous use of steroids in the management of covid-19 and uncontrolled diabetes mellitus has resulted in a tremendous rise in mucormycosis cases further burdening the already strained health care infrastructure and health care workers, especially the anesthesiologists. While working in a tertiary care institute of the country, we have been facing multiple challenges in its anesthetic management on a daily basis.

Automatic Brain Tumor Classification via Lion Plus Dragonfly Algorithm.

Denoising, skull stripping, segmentation, feature extraction, and classification are five important processes in this paper's development of a brain tumor classification model. The brain tumor image will be imposed first using the entropy-based trilateral filter to de-noising and this image is imposed to skull stripping by means of morphological partition and Otsu thresholding. Adaptive contrast limited fuzzy adaptive histogram equalization (CLFAHE) is also used in the segmentation process.

A Comparative Study of Isobaric 1% Chloroprocaine With 0.5% Isobaric Bupivacaine for Ureteroscopic Lithotripsy Under Spinal Anaesthesia: A Prospective Randomised Study.

Introduction Day-care surgery has become an immensely popular modality of treatment throughout the globe. Ureteroscopic lithotripsy (URSL) surgery is commonly performed on a day-care basis, and the duration of surgery ranges from 15 minutes to 45 minutes. URSL is routinely done under spinal anaesthesia.

Efficacy of Estradiol Cream for Venipuncture Pain in Obese Female Patients: A Pilot Study.

Introduction: Venipuncture is often a painful procedure causing significant anxiety, distress, and psychological consequences. We evaluated the efficacy of estradiol cream and compared it with a eutectic mixture of local anesthetics (EMLA) cream for alleviation of venipuncture pain and to make cannulation easy in female obese patients.

Materials And Methods: The clearance from the Institutional Ethical Committee as well as prior written and informed consent were obtained from the participants.

Protective role for properdin in progression of experimental murine atherosclerosis.

Genetic, dietary and immune factors contribute to the pathogenesis of atherosclerosis in humans and mice. Complement activation is an integral part of the innate immune defence but also shapes cellular responses and influences directly triglyceride synthesis. Deficiency of Factor B of the alternative pathway (AP) of complement is beneficial in LDLR(-/-) mice fed a high fat diet.

Azetidin-2-ones, synthon for biologically important compounds.

Azetidin-2-one, a four-membered cyclic lactam (beta-lactam) skeleton has been recognised as a useful building block for the synthesis of a large number of organic molecules by exploiting the strain energy associated with it, in addition to its use in the synthesis of a variety of beta-lactam antibiotics. Efforts have been made in exploring such new aspects of beta-lactam chemistry using enantiomerically pure beta-lactams as versatile intermediates for the synthesis of aromatic beta-amino acids and their derivatives, peptides, polyamines, polyamino alcohols, amino sugars and polyamino ethers. The development of methodologies based on beta-lactam nucleus is now referred as 'the beta-lactam synthon methods'.