Chromone-Based Cd(II) Fluorescent Coordination Polymer Fabricated to Study Optoelectronic and Explosive Sensing Properties.

Here, electrical conductivity and explosive sensing properties of multifunctional chromone-Cd(II)-based coordination polymers (CPs) (-) have been explored. The presence of different pseudohalide linkers, thiocyanate ions, and dicyanamide ions resulted in 1D and 3D architecture in the CPs. Thin film devices developed from CPs - (complex-based Schottky devices, , , , and , respectively) showed semiconductor behavior.

Exploring aryl hydrocarbon receptor (AhR) as a target for Bisphenol-A (BPA)-induced pancreatic islet toxicity and impaired glucose homeostasis: Protective efficacy of ethanol extract of Centella asiatica.

The estrogenic impact of Bisphenol-A (BPA), a widely recognized endocrine disruptor, causes disruption of pancreatic β-cell function through estrogen receptors (ERs). While BPA's binding affinity for ERs is significantly lower than that of its natural counterpart, estrogen, recent observations of BPA's affinity for aryl hydrocarbon receptor (AhR) in specific cellular contexts have sparked a specific question: does AhR play a role in BPA's toxicological effects within the endocrine pancreas? To explore this question, we investigated BPA's (10 and 100 μg/ kg body weight/day for 21 days) potential to activate AhR within pancreatic islets and assessed the protective role of ethanol extract of Centella asiatica (CA) (200 and 400 mg/kg body weight/day for 21 days) against BPA-mediated toxicity in mouse model. Our results indicate that BPA effectively triggers the activation of AhR and modulates its target genes within pancreatic islets.

Aza-phenol Based Macrocyclic Probes Design for "CHEF-on" Multi Analytes Sensor: Crystal Structure Elucidation and Application in Biological Cell Imaging.

Metal bound macrocyclic compounds found in biological systems inspired us to design and synthesize two Robson-type macrocyclic Schiff-base chemosensors, ( =1,11-dimethyl-6,16-dithia-3,9,13,19-tetraaza-1,11(1,3)-dibenzenacycloicosaphane-2,9,12,19-tetraene-1,11-diol) and =1,11-dimethyl-6,16-dioxa-3,9,13,19-tetraaza-1,11(1,3)-dibenzenacycloicosaphane-2,9,12,19-tetraene-1,11-diol). Both the chemosensors have been characterized with different spectroscopic techniques. They act as multianalyte sensor and exhibit "turn-on" fluorescence toward different metal ions in 1X PBS (Phosphate Buffered Saline) solution.

Selective Low-Level Detection of a Perilous Nitroaromatic Compound Using Tailor-Made Cd(II)-Based Coordination Polymers: Study of Photophysical Properties and Effect of Functional Groups.

Three coordination polymers (CPs -) are prepared based on diverse electron-donating properties and coordination arrangements of conjugated ligands. Interestingly, this is also reflected in their photophysical properties. The distinguishable high emissive nature of the luminescent coordination polymer shows its potentiality toward the detection of the perilous substance 2,4,6-trinitrophenol (TNP) or picric acid (PA).

Two rhodamine-azo based fluorescent probes for recognition of trivalent metal ions: crystal structure elucidation and biological applications.

Two rhodamine and azo based chemosensors (HL1 = (3',6'-bis(ethylamino)-2-((2-hydroxy-3-methoxy-5-(phenyldiazenyl)benzylidene)amino)-2',7'-dimethylspiro[isoindoline-1,9'-xanthen]-3-one) and HL2 = (3',6'-bis(ethylamino)-2-(((2-hydroxy-3-methoxy-5-(-tolyldiazenyl)benzylidene)amino)-2',7'-dimethylspiro[isoindoline-1,9'-xanthen]-3-one) have been synthesized for colorimetric and fluorometric detection of three trivalent metal ions, Al, Cr and Fe. The chemosensors have been thoroughly characterized by different spectroscopic techniques and X-ray crystallography. They are non-fluorescent due to the presence of a spirolactam ring.

Antibacterial potency of cytocompatible chitosan-decorated biogenic silver nanoparticles and molecular insights towards cell-particle interaction.

In the study, leaf extract of Carica papaya was utilized for the biogenic fabrication process of chitosan functionalized silver nanoparticles (Ag-Chito NPs). HRTEM analysis revealed that the fabricated Ag-Chito NPs was spherical in shape, with an average particle size of 13.31 (±0.

Aza-Crown-Based Macrocyclic Probe Design for "PET-off" Multi-Cu Responsive and "CHEF-on" Multi-Zn Sensor: Application in Biological Cell Imaging and Theoretical Studies.

The work represents a rare example of an aza-crown-based macrocyclic chemosensor, H (H = 1,16-dihydroxy-tetraaza-30-crown-8) for the selective detection of both Zn and Cu in HEPES buffer medium (pH 7.4). H exhibits a fluorescence response for both Zn and Cu ions.

Development of Rhodamine 6G-Based Fluorescent Chemosensors for Al-Ion Detection: Effect of Ring Strain and Substituent in Enhancing Its Sensing Performance.

Four rhodamine 6G-based chemosensors ( - ) are designed for selective detection of Al ion. They are characterized using various spectroscopic techniques and X-ray crystallography. All absorption and emission spectral studies have been performed in 10 mM -(2-hydroxyethyl)piperazine-'-ethanesulfonic acid (HEPES) buffer solution at pH 7.

Bioequivalence of two tacrolimus formulations under fasting conditions in healthy male subjects.

Background: Tacrolimus is a macrolide immunosuppressant indicated for prophylaxis of transplant rejection. The European regulatory authorities require comparative bioavailability studies with an innovator product to grant marketing authorization of generic products.

Objective: The purpose of this study was to test the bioequivalence of generic (test) and innovator (reference) tacrolimus capsules.

Single-dose, two-way crossover, bioequivalence study of Mycophenolate mofetil 500 mg tablet under fasting conditions in healthy male subjects.

Background: Mycophenolate mofetil (MMF) is an immunosuppressant indicated for prophylaxis of acute organ transplant rejection. Generic MMF is less costly than the branded product, but European regulatory authorities require bioequivalence studies for the marketing of generics.

Objectives: The aims of the 2 studies reported were to assess the dissolution and bioavailability of a generic (test) and branded (reference) formulation of MMF 500 mg.

Nanosomal Amphotericin B is an efficacious alternative to Ambisome for fungal therapy.

Amphotericin B was formulated in lipids (Nanosomal Amphotericin B) without using any detergent or toxic organic solvents during the preparation. Electron microscopy and particle size determination of Nanosomal Amphotericin B showed a homogeneous population of nanosized particles below 100 nm. Hemolysis assay indicated that Nanosomal Amphotericin B causes significantly less lysis of red blood cells than Amphotericin B deoxycholate and was comparable to Ambisome.