Piezoelectric Amyloid Fibril for Energy Harvesting, Reactive Oxygen Species Generation, and Wireless Cell Therapy.

Biomolecular piezoelectric materials are envisioned for advanced biomedical applications for their robust piezoelectricity, biocompatibility, and flexibility. Here, we report the piezoelectric property of amyloid fibrils derived from three distinct proteins: lysozyme, insulin, and amyloid-β. We found that piezoelectric properties are dependent on the extent of the β-sheet structure and the extent of fibril anisotropy.

Ultrasonic Electroporation for Cells Grown on Piezoelectric Film Composed of Hydroxyapatite Nanowire and PVDF.

The delivery of cell impermeable exogenous material into live cells by external stimuli is critical for both biological research and therapeutic applications. Although electroporation-based delivery of foreign materials inside the cell is a powerful approach, cell viability is often compromised due to the requirement of high voltage. Here, we report a piezoelectric hydroxyapatite nanowire-embedded poly(vinylidene fluoride) (PVDF) film for ultrasonic electroporation-based delivery of foreign materials to adherent cells.

Biodegradable Poly(trehalose) Nanoparticle for Preventing Amyloid Beta Aggregation and Related Neurotoxicity.

Trehalose is a disaccharide that is capable of inhibiting protein aggregation and activating cellular autophagy. It has been shown that a polymer or nanoparticle form, terminated with multiple trehalose units, can significantly enhance the anti-amyloidogenic performance and is suitable for the treatment of neurodegenerative diseases. Here, we report a trehalose-conjugated polycarbonate--lactide polymer and formulation of its nanoparticles having multiple numbers of trehalose exposed on the surface.

Enhanced Piezocatalysis by Calcium Phosphate Nanowires via Gold Nanoparticle Conjugation.

Piezocatalytic materials have considerable application potential in wireless therapy. Most of these applications require biocompatible nanomaterials for in vivo targeting and control of intracellular processes. However, the piezocatalytic performance of a material decreases at a nanometer size regime, and most of the biocompatible materials have poor piezocatalytic efficiency.