HPTLC method to support formulation development and quality control of the tablets prepared from fruit extracts of .

Alcoholic extract of fruits of is reported to have antihypertensive activity, significantly due to presence of alkaloids like piperine, piperlongumine, piperlonguminine and pipernonaline. A sensitive and specific HPTLC method was developed and validated for simultaneous estimation of piperine, piperlongumine and piperlonguminine in fruit extracts with a purpose to provide the analytical support during the development of formulation as well as to serve as a quality control tool for optimised formulation. Developed method was validated with respect to ICH (International Council for Harmonisation) Q2(R1) and found to be accurate, precise, sensitive, specific and robust for estimation of piperine, piperlongumine and piperlonguminine.

COVID-19 and vaccination: myths vs science.

Introduction: Several vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed since the inception of the coronavirus disease 2019 (COVID-19) in December 2019, at unprecedented speed. However, these rapidly developed vaccines raised many questions related to the efficacy and safety of vaccines in different communities across the globe. Various hypotheses regarding COVID-19 and its vaccines were generated, and many of them have also been answered with scientific evidence.

Simultaneous Estimation of Six Nitrosamine Impurities in Valsartan Using Liquid Chromatographic Method.

Background: Nitrosamine impurities are potent carcinogens in animals and probable carcinogens in humans. There is a need for effective analytical methods to detect and identify various nitrosamine impurities, and to develop rapid solutions to ensure the safety and quality of the drugs.

Objective: A liquid chromatographic method was developed for estimation of six nitrosamine impurities in valsartan.

Determination of galantamine hydrobromide in bulk drug and pharmaceutical dosage form by spectrofluorimetry.

Aim: To develop a simple, accurate, sensitive, rapid and precise method for the determination of galantamine hydrobromide in bulk drug and pharmaceutical dosage form.

Material And Methods: The method employs wavelength detection and determination of galantamine hydrobromide at excitation wavelength 282 nm and emission wavelength 607 nm in a solution of simple distilled water.

Result And Conclusion: The method was found to be linear in the range of 2-14 μg/ml having r (2) = 0.

Absorbance correction method for estimation of telmisartan and metoprolol succinate in combined tablet dosage forms.

Aim And Background: The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of telmisartan and metoprolol succinate in combined tablet dosage form.

Materials And Methods: The method is based on the absorbance correction equations for analysis of both the drugs using methanol as solvent. Telmisartan has absorbance maxima at 296 nm and metoprolol succinate has absorbance maxima at 223 nm in methanol.

Stress degradation studies on Telmisartan and development of a validated method by UV spectrophotometry in bulk and pharmaceutical dosage forms.

Aim And Background: To develop and validate a simple, precise, accurate, and stability indicating a UV-method for estimation of Telmisartan (TELM). UV, HPLC, HPTLC, and many more experiments were carried out by taking single drug and also by combining with other drugs. However, Such type of studies was not reported.

Stability-indicating high-performance thin-layer chromatographic method for analysis of itraconazole in bulk drug and in pharmaceutical dosage form.

Background: A new, simple, selective, precise, and stability-indicating high-performance thin-layer chromatographic method has been established for analysis of itraconazole (ITZ) in the bulk drug and in pharmaceutical formulations. Separation was achieved on aluminium plate precoated with silica gel 60F254 using Toluene : Chloroform : Methanol [5: 5: 1.5(v/v)] as mobile phase.