Nanoparticles Induced Biomimetic Remineralization of Acid-Etched Dentin.

Statement Of The Problem: Dentin bonding with etch-and-rinse adhesives involves demineralizing the 5-8µm of the surface dentin to create micro space for resin infiltration. The presence of continuous fluid movement in dentin tubules and positive pulpal pressure prevents complete water replacement by resin monomers. This results in areas of demineralized dentin, which contain collagen fibers without resin infiltration.

Breaking the storm: ruxolitinib as a lifeline in refractory hemophagocytic lymphohistiocytosis with macrophage activation syndrome.

This case report presents the management of a 25-year-old woman with refractory hemophagocytic lymphohistiocytosis (HLH) secondary to adult-onset Still's disease. Despite initial treatment with corticosteroids and biologic therapies, including anakinra and tocilizumab, her condition continued to deteriorate, necessitating intensive care unit admission. Following multidisciplinary consultation, ruxolitinib therapy, a Janus kinase (JAK) inhibitor targeting hyperinflammation, was initiated.

A Longitudinal Interview Study of People with Long COVID: Uncertainties, Liminality, and Processes of Becoming.

Current estimates indicate around 6% of US adults have experienced long COVID symptoms. Given the novelty of both COVID and long COVID, those who continue to be ill after an initial SARS-CoV-2 infection have little precedence on which to rely when navigating the medical (e.g.

Exosome-mediated delivery of CRISPR-Cas9: A revolutionary approach to cancer gene editing.

Several molecular strategies based on targeted gene delivery systems have been developed in recent years; however, the CRISPR-Cas9 technology introduced a new era of targeted gene editing, precisely modifying oncogenes, tumor suppressor genes, and other regulatory genes involved in carcinogenesis. However, efficiently and safely delivering CRISPR-Cas9 to cancer cells across the cell membrane and the nucleus is still challenging. Using viral vectors and nanoparticles presents issues of immunogenicity, off-target effects, and low targeting affinity.

Dehydrogenative Coupling of Alcohols with Hydrazines under Nickel Catalysis.

The development of efficient and robust catalytic systems based on earth-abundant transition metals for fundamentally new transformations is crucial for sustainable chemical synthesis. Herein, an effective and selective Ni-catalyzed dehydrogenative coupling of alcohols with hydrazines with the liberation of ammonia gas is reported. Although several methods were documented for the -alkylation reaction, the present strategy is conceptually novel, and the reaction proceeds through a pathway involving N-N bond cleavage of phenylhydrazine followed by hydrogen autotransfer.

Clinician Perspectives Highlight the Need for Early Dyadic Coping Skills for People Living with Amyotrophic Lateral Sclerosis.

Context: A diagnosis of ALS can be challenging, and many people find ways to adapt. At the same time, emotional distress can arise early after an ALS diagnosis even when high quality multidisciplinary care is provided. When emotional distress occurs, it can become chronic over time, and can affect both the person living with ALS and their care-partner (together called a dyad).

Liquid biopsies and exosomal ncRNA: Transforming pancreatic cancer diagnostics and therapeutics.

Pancreatic cancer is a highly fatal malignancy due to poor early detection rate and resistance to conventional therapies. This review examines the potential for liquid biopsy as a transformative technology to identify diagnostic and therapeutic targets in pancreatic cancer. Specifically, we explore emerging biomarkers such as exosomal non-coding RNAs (ncRNAs), circulating tumor DNA (ctDNA), and circulating tumor cells (CTCs).

Short- and long-term alterations of hematopoietic cell lineages in rats with congenital iron deficiency.

Data support that fetal iron delivery is prioritized to hemoglobin in erythrocytes (RBC). Iron deficiency (ID) during pregnancy can cause congenital ID, i.e.

Telemedicine and information technology in health care management: Perspectives and barriers among the nursing students.

Background: Telemedicine refers to using electronic information and telecommunication technologies to support numerous aspects of healthcare, including clinical care, patient and professional education and training, public health, and health administration. However, many challenges hinder the widespread adoption of telemedicine by healthcare providers. This study aimed to assess the perspectives and barriers in telemedicine and information technology in health care management among nursing students.

Targeted nanoparticle delivery unleashes synergistic photothermal and immunotherapeutic effects against hepatocellular carcinoma.

The substantial mortality and morbidity of hepatocellular carcinoma, representing 90% of liver cancers, poses a significant health burden. The effectiveness of traditional hepatocellular carcinoma treatments such as surgical resection, radiotherapy, and chemotherapy is limited, underscoring the need for innovative therapeutic strategies. To this end, we synthesized phthalyl-pullulan nanoparticles encapsulating IR780 (an NIR-responsive heptamethine cyanine dye) and R848 (resiquimod; a TLR7/8 agonist) (PIR NPs).

Exploring the genetic diversity and population structure of an ancient hexaploid wheat species Triticum sphaerococcum using SNP markers.

Background: Understanding genetic diversity and population structure is crucial for strategizing and enhancing breeding efficiency. Wheat, a globally cultivated crop, is a significant source of daily calories for humans. To overcome challenges such as extreme climatic fluctuations, stagnant yields, and diminishing genetic variation, it is essential to develop diverse germplasms with new alleles.

Size and canopy characteristics of community reserves determine primate occupancy in the state of Meghalaya, India, and implications for its conservation.

Globally, the effective protected area network is one of the last resorts for conserving biodiversity. The nature of protected areas depends on the land ownership of the respective countries including India. The landholding in the northeastern states of India remains with native people, thus, 'Community Reserve' (CR) was introduced in 2003.

Interplay of geometry and mechanics in epithelial wound healing.

Wound healing is a complex biological process critical for maintaining an organism's structural integrity and tissue repair following an infection or injury. Recent studies have unveiled the mechanisms involving the coordination of biochemical and mechanical responses in the tissue in wound healing. In this article, we focus on the healing property of an epithelial tissue as a material while the effects of biological mechanisms such as cell proliferation, tissue intercalation, cellular migration, cell crawling, and filopodia protrusion is minimal.

Assessment of Lead Exposure and Associated Risk Through Human Biomonitoring Among Urban Communities in Chennai, Southern India.

Background: Lead exposure is a widely acknowledged risk to public health for children and adults. However, despite efforts to phase out major sources over the last several decades, estimates of the prevalence of blood lead exposures and associated risks remain poorly characterized in many low- and middle-income countries.

Objectives:  This study aimed to determine blood lead levels (BLLs) and assess potential sources of lead exposure among urban communities in Chennai, Tamil Nadu.

Corrigendum: Perceptions of primary healthcare providers for screening and management of mental health disorders in India: a qualitative study.

[This corrects the article DOI: 10.3389/fpubh.2024.

Influence of Biological Sex and Congenital Iron Deficiency on Neonatal Cytokine Responses.

Background/objectives: Stimulated cord blood mononuclear cell (CBMC) cytokine responses were previously shown to predict the risk of childhood atopic disease. Iron deficiency (ID) at birth may also program atopic disease. Males are at a higher risk of pediatric atopic disease, but it is not known whether congenital ID impacts CBMC immune responses differentially by sex.

World Stroke Organization and World Hypertension League Position Statement on Hypertension Control Strategies in Prevention and Management of Stroke.

Background And Purpose:-: The goal of this consensus is to provide a comprehensive set of recommendations regarding hypertension control strategies for the prevention and management of stroke. This document is intended for prehospital care providers, physicians, allied health professionals, and hospital administrators and health care policy makers.

Methods:-: Members of the writing group were representatives of the World Stroke Organization and World Hypertension League.

MUCORMYCOSIS: Re-emerging opportunistic fungal infections in COVID-19 pandemic times in Indian patients (South Indian) - A series of seven cases.

Opportunistic fungal infections are associated with patients having compromised systemic health. In India, a slow rise in cases of mucormycosis has been observed as the country has seen a rising number of diabetes mellitus cases in the recent decades. This apart, an enormous increase in case numbers was seen in association with COVID-19 infections in the Asian subcontinent, Southeast Asia, markedly in India.

A rare giant renal angiomyolipoma in a 17-year-old male: A case report.

Unlabelled: Renal angiomyolipoma is an uncommon benign tumor that mostly affects adults and is highly associated with tuberous sclerosis. It's very uncommon for it to affect adolescents. In this case, a 17-year-old male with abdominal pain and distension was diagnosed with sporadic giant renal angiomyolipoma.